Page 120 - IJB-4-2
P. 120
Shuai C, et al.
6. The Opportunities and Challenges of with BMP-7, autologous bone graft and hydroxyapatite
Physical Stimulations pellets. Injury, 47: S71–S77. https://doi.org/10.1016/
Physical stimulations have been demonstrated to be j.injury.2016.07.044
effective in promoting bone repair. It is urgently require 5. Schwartz A M, Schenker M L, Ahn J, et al., 2017, Building
further systematic investigations to find the underlying better bone: The weaving of biologic and engineering
mechanisms, thereby getting better understanding of the strategies for managing bone loss. J Orthop Res, 35(9):
bioeffects and providing adequate theoretical supports 1855–1864. https://doi.org/10.1002/jor.23592
for the application in bone repair. Bone is a dynamic 6. Shuai C, Feng P, Wu P, et al., 2016, A combined
tissue composed of several cell types such as osteocytes, nanostructure constructed by graphene and boron nitride
osteoblasts, osteoclasts and bone mesenchymal stem nanotubes reinforces ceramic scaffolds. Chemical
cells. The cells play an important role in maintaining Engineering Journal, 313: 487–497. https://doi.org/10.1016/
normal bone homeostasis. Current researches mainly j.cej.2016.11.095
focus on the bone formation by osteoblasts. Therefore,
future researches should comprehensively evaluate the 7. Feng P, Wu P, Gao C, et al., 2018, A multi-material scaffold
bioeffects of physical stimulations on various cells, with tunable properties: Towards bone tissue repair.
and the mutual regulation between cells under physical Advanced Science, 1700817: 1–15.
stimulations should also be considered. 8. Hu K, Olsen B R, 2016, The roles of vascular endothelial
growth factor in bone repair and regeneration. Bone, 91:
Acknowledgements
30–38. https://doi.org/10.1016/j.bone.2016.06.013
This work was supported by the following funds: (1) 9. Yang F, Wang J, Hou J, et al., 2013, Bone regeneration using
The Natural Science Foundation of China (51575537, cell-mediated responsive degradable PEG-based scaffolds
81572577, 51705540); (2) Hunan Provincial Natural incorporating with rhBMP-2. Biomaterials, 34(5): 1514–
Science Foundation of China (2016JJ1027); (3) The 1528. https://doi.org/10.1016/j.biomaterials.2012.10.058
Project of Innovation-driven Plan of Central South
University (2016CX023); (4) The Open-End Fund for 10. Rumpler M, Woesz A, Manjubala I, et al., 2010, Three-
the Valuable and Precision Instruments of Central South dimensional growth behavior of osteoblasts on biomimetic
University; (5) The fund of the State Key Laboratory of hydroxylapatite scaffolds. J Biomed Mater Res A, 81(1):
Solidification Processing in NWPU (SKLSP201605); (6) 40–50. https://doi.org/10.1002/jbm.a.30940
National Postdoctoral Program for Innovative Talents 11. Zhang H, Ahmad M, Gronowicz G, 2003, Effects of
(BX201700291); (7) The Project of State Key Laboratory transforming growth factor-beta 1 (TGF-1) on in vitro
of High Performance Complex Manufacturing; (8) The mineralization of human osteoblasts on implant materials.
Project of Hunan Provincial Science and Technology Biomaterials, 24(12): 2013–2020. https://doi.org/10.1016/
Plan (2017RS3008). S0142-9612(02)00616-6
References 12. Zhu Y, Yang Q, Yang M, et al., 2017, Protein corona of
magnetic hydroxyapatite scaffold improves cell proliferation
1. Dhand C, Ong S T, Dwivedi N, et al., 2016, Bio-inspired in via activation of mitogen-activated protein kinase signaling
situ crosslinking and mineralization of electrospun collagen pathway. Acs Nano, 11(4): 3690–3704. https://doi.
scaffolds for bone tissue engineering. Biomaterials, 104: org/10.1021/acsnano.6b08193
323–338. https://doi.org/10.1016/j.biomaterials.2016.07.007 13. Puricelli E, Dutra N B, Ponzoni D, 2009, Histological
2. Naveena N, 2012, Biomimetic composites and stem cells evaluation of the influence of magnetic field application in
interaction for bone and cartilage tissue regeneration. J autogenous bone grafts in rats. Head Face Med, 5: 1. https://
Mater Chem, 22(12): 5239–5253. https://doi.org/10.1039/ doi.org/10.1186/1746-160X-5-1
C1JM14401D 14. Kim I S, Song J K, Zhang Y L, et al., 2006, Biphasic
3. Praemer A, Furner S, Rice D P, 1992, Musculoskeletal electric current stimulates proliferation and induces VEGF
conditions in the United States. Amer Academy of production in osteoblasts. Biochim Biophys Acta, 1763(9):
Orthopaedic. 907–916. https://doi.org/10.1016/j.bbamcr.2006.06.007
4. Caterini R, Potenza V, Ippolito E, et al., 2016, Treatment 15. Muttini A, 2014, Effect of electric current stimulation in
of recalcitrant atrophic non-union of the humeral shaft
combination with external fixator on bone healing in a
International Journal of Bioprinting (2018)–Volume 4, Issue 2 13

