Page 271 - IJB-10-4

International

Journal of Bioprinting

RESEARCH ARTICLE
Personalized light-curable polyurethane palatal

prosthesis designed and fabricated based on
computer fluid dynamics and 3D printing to

repair palatal fistula

Qiwei Chen , Haihuan Gong , Yilin Wang , Yanyan Zhao , Hong Zhao ,
2†
1†
1
4
3
Zhiwei Lin , Jingya Yang , Manoj Kumar Vashisth , Lixiang Zhao ,
6,7
5
8
1
Yunlu Dai *, and Wenhua Huang 1,4,6 *
9
1 Department of Anatomy, Guangdong Provincial Key Laboratory of Medical Biomechanics, School
of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
2 Department of Periodontics, Affiliated Stomatology Hospital of Guangzhou Medical University,
Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine,
Guangzhou, Guangdong, China
3 Department of Science and Education, The Second Affiliated Hospital of Henan University of
Science and Technology, Luoyang, Henan, China
4 Department of Nursing and Health, Huizhou Economics and Polytechnic College, Huizhou,
Guangdong, China
5
School of Basic Medical Sciences, Guangdong Medical University, Dongguan, Guangdong, China
6 Department of Otolaryngology - Head and Neck Surgery, The Third Affiliated Hospital of Southern
Medical University, Guangzhou, Guangdong, China
† These authors contributed equally 7
to this work. School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China
8 Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical
*Corresponding authors: University, Nanning, Guangxi, China
Wenhua Huang
(Huangwenhua2009@139.com) 9 Faculty of Health Sciences and MoE Frontiers Science Center for Precision Oncology, University
of Macau, Macau, China
Yunlu Dai
(yldai@um.edu.mo)
Citation: Chen Q, Gong H, Wang Y,
et al. Personalized light-curable
polyurethane palatal prosthesis Abstract
designed and fabricated based on
computer fluid dynamics and 3D Cleft palate surgery most commonly results in palatal fistula, but this complication
printing to repair palatal fistula. can also be observed in congenital malformations, palatal tumors, and autoimmune
Int J Bioprint. 2024;10(4):2516.
doi: 10.36922/ijb.2516 diseases. Palatal fistula repair is crucial in restoring everyday speech and swallowing
function, improving patients’ psychological and social well-being. However, treating
Received: December 23, 2023
Accepted: February 15, 2024 palatal fistula remains challenging for oral and maxillofacial surgeons. In addition,
Published Online: March 19, 2024 fabricating a palatal fistula prosthesis with a precise fit to the fistula using traditional
Copyright: © 2024 Author(s). techniques is hardly achievable in the design and production process. In recent
This is an Open Access article years, digital technology has been increasingly applied in palatal fistula prosthesis
distributed under the terms of the fabrication. Based on computer fluid dynamics (CFD)-assisted design and three-
Creative Commons Attribution
License, permitting distribution, dimensional printing technology, we developed a personalized palatal prosthesis
and reproduction in any medium, made of light-cured polyurethane to repair palatal fistula and restore normal airflow
provided the original work is during speech. Material property tests show that this light-cured polyurethane
properly cited.
material has excellent hydrophilicity, mechanical properties, water resistance, and
Publisher’s Note: AccScience good rheological performance. The excellent biocompatibility of the polyurethane
Publishing remains neutral with palatal prosthesis was confirmed in in vivo and in vitro experiments. The study results
regard to jurisdictional claims in
published maps and institutional also indicate that CFD pre-analysis provides accurate guidance for palatal fistula
affiliations. design and future evaluation of outcomes. Therefore, CFD pre-analysis and additive

Volume 10 Issue 4 (2024) 263 doi: 10.36922/ijb.2516