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International Journal of Bioprinting 3D printed hydrogels for tumor therapy

were homogenously dispersed within the hydrogels. The Consent for publication
incorporation of MgHAp nanocomposites improved the Not applicable.
printability of inks and promoted structural fidelity of
printed structures. Additionally, MgHAp nanocomposites Availability of data
enhanced the mechanical strength of hydrogels. Moreover,
MgHAp/GelMA-PDA@DOX hydrogels enabled the Data are available from the corresponding author upon
sustained and controlled release of Mg . MgHAp/GelMA- reasonable request.
2+
PDA@DOX hydrogels exhibited an excellent photothermal
effect and could generate hyperthermia upon irradiation References
with NIR laser. The release of DOX from hydrogels could
be controlled by NIR laser irradiation and was also pH- 1. Isakoff MS, Bielack SS, Meltzer P, Gorlick R. Osteosarcoma:
responsive. In vitro antitumor experiments indicated that current treatment and a collaborative pathway to success. J
MgHAp/GelMA-PDA@DOX hydrogels could effectively Clin Oncol. 2015;33(27):3029-3035.
kill the MG63 osteosarcoma cells through the synergistic doi: 10.1200/JCO.2014.59.4895
effect of induced hyperthermia and DOX release. Moreover, 2. Chen HHW, Kuo MT. Improving radiotherapy in
compared to HAp/GelMA hydrogels, MgHAp/GelMA- cancer treatment: promises and challenges. Oncotarget.
PDA hydrogels could promote proliferation and osteogenic 2017;8(37):62742-62758.
differentiation of rBMSCs due to the sustained release of doi: 10.18632/oncotarget.18409
Mg . Consequently, 3D-printed MgHAp/GelMA-PDA@ 3. Behranvand N, Nasri F, Zolfaghari Emameh R, et al.
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DOX hydrogels hold great promise in treating bone tumor- Chemotherapy: a double-edged sword in cancer treatment.
related defects by providing effective anti-tumor efficiency Cancer Immunol Immunother. 2022;71(3):507-526.
and the promotion of osteogenic effect. doi: 10.1007/s00262-021-03013-3
4. Su J, Sun H, Meng Q, et al. Bioinspired nanoparticles
Acknowledgments with NIR‐controlled drug release for synergetic
chemophotothermal therapy of metastatic breast cancer.
None
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doi: 10.1002/adfm.201603381
Funding
5. Fan R, Chen C, Hou H, et al. Tumor acidity and near‐
This work was financially supported by the National infrared light responsive dual drug delivery polydopamine‐
Nature Science Foundation of China (Grant No. 82201133) based nanoparticles for chemo‐photothermal therapy. Adv
and Fong On Construction Ltd. in Hong Kong (Grant No. Funct Mater. 2021;31(18):2009733.
ZDBM, ZDCA). The research sponsored from Fong On doi: 10.1002/adfm.202009733
Construction Ltd. (HK) has potential interest in exploring 6. An D, Fu J, Zhang B, et al. NIR‐II responsive inorganic
the potential application of extrusion-based 3D printing 2D nanomaterials for cancer photothermal therapy:
technology in automation within the construction industry. recent advances and future challenges. Adv Funct Mater.
2021;31(32):2101625.
Conflict of interest doi: 10.1002/adfm.202101625

The authors declare no conflicts of interest. 7. Ren Y, Yan Y, Qi H. Photothermal conversion and transfer in
photothermal therapy: from macroscale to nanoscale. Adv
Author contributions Colloid Interface Sci. 2022;308:102753.
doi: 10.1016/j.cis.2022.102753
Conceptualization: Shangsi Chen, Shenglong Tan 8. Batul R, Tamanna T, Khaliq A, Yu A. Recent progress in the
Investigation: Shangsi Chen, Yue Wang, Junzhi Li biomedical applications of polydopamine nanostructures.
Methodology: Shangsi Chen, Yue Wang, Junzhi Li Biomater Sci. 2017;5(7):1204-1229.
Supervision: Haoran Sun, Ming-Fung Francis Siu, doi: 10.1039/c7bm00187h
Shenglong Tan
Writing – original draft: All authors 9. Qiu J, Shi Y, Xia Y. Polydopamine nanobottles with
photothermal capability for controlled release and related
Writing – review & editing: Haoran Sun, Ming-Fung applications. Adv Mater. 2021;33(45):e2104729.
Francis Siu, Shenglong Tan doi: 10.1002/adma.202104729

Ethics approval and consent to participate 10. Bedhiafi T, Idoudi S, Alhams AA, et al. Applications of
polydopaminic nanomaterials in mucosal drug delivery.
Not applicable. J Control Release. 2023;353:842-849.

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