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REVIEW ARTICLE

Engineering a Model to Study Viral

Infections: Bioprinting, Microfluidics, and Organoids to

Defeat Coronavirus Disease 2019 (COVID-19)

Anastasia Shpichka *, Polina Bikmulina , Maria Peshkova , Nastasia Kosheleva , Irina
1†
1†
1,2
3,4
Zurina , Ensieh Zahmatkesh , Niloofar Khoshdel-Rad , Marina Lipina , Elena Golubeva ,
2
7
5,6
1,3
5,6
Denis Butnaru , Andrei Svistunov , Massoud Vosough *, Peter Timashev 1,2,9 *
8
8
5,6
1 Department of Advanced Biomaterials, Institute for Regenerative Medicine, Sechenov University, Moscow, Russia
2 Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia
3 Department of Molecular and Cell Pathophysiology, FSBSI Institute of General Pathology and Pathophysiology, Moscow, Russia
4 Department of Embryology, Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia
5 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology,
ACECR, Tehran, Iran
6 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology
and Technology, ACECR, Tehran, Iran
7 Department of Traumatology, Orthopedics and Disaster Surgery, Sechenov University, Moscow, Russia
8 Rector’s Office, Sechenov University, Moscow, Russia
9 Department of Polymers and Composites, NN Semenov Institute of Chemical Physics, Moscow, Russia
† These authors contributed equally to this work.

Abstract: While the number of studies related to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is
constantly growing, it is essential to provide a framework of modeling viral infections. Therefore, this review aims to describe
the background presented by earlier used models for viral studies and an approach to design an “ideal” tissue model for
SARS-CoV-2 infection. Due to the previous successful achievements in antiviral research and tissue engineering, combining
the emerging techniques such as bioprinting, microfluidics, and organoid formation are considered to be one of the best
approaches to form in vitro tissue models. The fabrication of an integrated multi-tissue bioprinted platform tailored for SARS-
CoV-2 infection can be a great breakthrough that can help defeat coronavirus disease in 2019.

Keywords: Severe acute respiratory syndrome-related coronavirus 2, Coronavirus disease 2019, Coronavirus, Bioprinting,
microfluidics, Organoids, Tissue models, Viral infection, Body-on-a-chip

*Corresponding Authors: Anastasia Shpichka, Institute for Regenerative Medicine, Sechenov University, Moscow, Russia: ana-shpichka@
yandex.ru; Massoud Vosough, Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and
Technology, ACECR, Tehran, Iran: masvos@royaninstitute.org; Peter Timashev, Institute for Regenerative Medicine, Sechenov University,
Moscow, Russia: timashev.peter@gmail.com
Received: June 30, 2020; Accepted: July 15, 2020; Published Online: August 28, 2020

(This article belongs to the Special Section: Research and Applications of 3D Printing and Bioprinting for Covid-19)
Citation: Shpichka S, Bikmulina P, Peshkova M, et al., 2020. Engineering a Model to Study ViralInfections: Bioprinting,
Microfluidics, and Organoids to Defeat Coronavirus Disease 2019 (COVID-19) , Int J Bioprint, 6(4): 302. DOI: 10.18063/
ijb.v6i4.302.

© 2020 Shpichka, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International
License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the
original work is properly cited.
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