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Soman and Vijayavenkataraman
environments. Hence, development of suitable 9. Sridharan R, Tchieu J, Mason MJ, et al., 2009, Role of
post-processing strategies such as integrated the Murine Reprogramming Factors in the Induction
perfusion bioreactor systems becomes necessary. of Pluripotency. Cell, 136:364–77. DOI: 10.1016/j.
• Pathway for clinical translation: A coordinated cell.2009.01.001.
effort between the clinicians, scientists, and
bioengineers in solving the technological 10. Kim JB, Greber B, Arazo-Bravo MJ, et al., 2009, Direct
limitations and support from the government Reprogramming of Human Neural Stem Cells by OCT4.
and policy-makers would go a long way in Nature, 461:649–53. DOI: 10.1038/nature08436.
establishing a pathway for clinical translation 11. Stadtfeld M, Hochedlinger K, 2010, Induced Pluripotency:
of bioprinted iPSC-derived tissues for History, Mechanisms, and Applications. Genes Dev,
regenerative medicine, disease modeling and
drug testing. 24:2239–63. DOI: 10.1101/gad.1963910.
12. Yee JK, 2010, Turning Somatic Cells into Pluripotent Stem
Conflicts of interest Cells. Nat Educ, 3:25.
13. Mertens J, Reid D, Lau S, et al., 2018, Aging in a Dish:
The authors declare no conflict of interest. iPSC-Derived and Directly Induced Neurons for Studying

References Brain Aging and Age-Related Neurodegenerative Diseases.
Annu Rev Genet, 52:271–93. DOI: 10.1146/annurev-
1. Takahashi K, Yamanaka S, 2006, Induction of Pluripotent genet-120417-031534.
Stem Cells from Mouse Embryonic and Adult Fibroblast 14. Penney J, Ralvenius WT, Tsai LH, 2019, Modeling
Cultures by Defined Factors. Cell, 126:663–76. Alzheimer’s Disease with iPSC-Derived Brain Cells. Mol
DOI: 10.1016/j.cell.2006.07.024. Psychiatry, 25:148–67. DOI: 10.1038/s41380-019-0468-3.
2. Yu J, Vodyanik MA, Smuga-Otto K, et al., 2007, Thomson, 15. Chen IY, Matsa E, Wu JC, 2016, Induced Pluripotent Stem
Induced Pluripotent Stem Cell Lines Derived from Human Cells: At the Heart of Cardiovascular Precision Medicine. Nat
Somatic Cells. Science, 318:1917–20. DOI: 10.1126/ Rev Cardiol, 13:333–49. DOI: 10.1038/nrcardio.2016.36.
science.1151526. 16. Koch L, Deiwick A, Franke A, et al., 2018, Laser
3. Zhang Y, Chen K, Sloan SA, et al., 2004, An RNA-sequencing Bioprinting of Human Induced Pluripotent Stem Cells
Transcriptome and Splicing Database of Glia, Neurons, and the Effect of Printing and Biomaterials on Cell Survival,
Vascular Cells of the Cerebral Cortex. J Neurosci, 34:11929– Pluripotency, and Differentiation. Biofabrication, 10:035005.
47. DOI: 10.1523/jneurosci.1860-14.2014. DOI: 10.1088/1758-5090/aab981.
4. Chappell J, Dalton S, 2013, Roles for MYC in the 17. Maiullari F, Costantini M, Milan M, et al., 2018, A Multi-
Establishment and Maintenance of Pluripotency. Cold Spring cellular 3D Bioprinting Approach for Vascularized Heart
Harb. Perspect Med, 3:a014381. DOI: 10.1101/cshperspect. Tissue Engineering Based on HUVECs and iPSC-Derived
a014381. Cardiomyocytes. Sci Rep, 8:13532. DOI: 10.1038/s41598-
5. Zhang P, Zhang X, Brown J, et al., 2010, Global Healthcare 018-31848-x.
Expenditure on Diabetes for 2010 and 2030. Diabetes Res 18. Yeung E, Fukunishi T, Bai Y, et al., 2019, Cardiac
Clin Pract, 87:293–301. DOI: 10.1016/j.diabres.2010.12.025. Regeneration Using Human-induced Pluripotent Stem Cell-
6. Han JW, Yoon YS, 2011, Induced Pluripotent Stem Cells: derived Biomaterial-free 3D-bioprinted Cardiac Patch In Vivo.
Emerging Techniques for Nuclear Reprogramming. J Tissue Eng Regen Med, 13:2031-9. DOI: 10.1002/term.2954.
Antioxidants Redox Signal, 15:1799–820. DOI: 10.1089/ 19. Faulkner-Jones A, Fyfe C, Cornelissen DJ, et al., 2015,
ars.2010.3814. Bioprinting of Human Pluripotent Stem Cells and their
7. An Z, Liu P, Zheng J, et al., 2019, Sox2 and Klf4 as the Functional Directed Differentiation into Hepatocyte-like Cells for the
Core in Pluripotency Induction without Exogenous Oct4. Cell Generation of Mini-livers in 3D. Biofabrication, 7:044102.
Rep, 29:1986–2000. DOI: 10.1016/j.celrep.2019.10.026. doi.org/10.1088/1758-5090/7/4/044102.
8. Chen IP, Fukuda K, Fusaki N, et al., 2013, Induced 20. Nguyen HX, Hooshmand MJ, Saiwai H, et al., 2017,
Pluripotent Stem Cell Reprogramming by Integration-free Systemic Neutrophil Depletion Modulates the Migration and
Sendai Virus Vectors from Peripheral Blood of Patients with Fate of Transplanted Human Neural Stem Cells to Rescue
Craniometaphyseal Dysplasia. Cell Reprogram, 15:503–13. Functional Repair. J Neurosci, 37:9269–87. DOI: 10.1523/
DOI: 10.1089/cell.2013.0037. jneurosci.2785-16.2017.
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