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International Journal of Bioprinting 3D-Printed Zn/MgHA-PCL for angio/osteogenesis

Figure 8. Staining of α-SMA, CD31, and COL I during bone formation after composite scaffold implantation for 1 and 3 months. Scale bar: 400 μm.
Abbreviations: HA, hydroxyapatite; PCL, polycaprolactone.

4. Conclusion Acknowledgments
In this study, HA, Zn-doped HA, and Mg/Zn-co-doped The authors would like to acknowledge the
HA were successfully synthesized via hydrothermal creation of Graphical abstract and Figure 1 using
synthesis. After compounding with PCL, porous scaffolds BioRender (biorender.com).
were fabricated via 3D printing. Experimental results
demonstrated excellent mechanical properties, making Funding
them suitable for repairing load-bearing bone defects. In
vitro experiments confirmed good biocompatibility of all This work was supported by the National Key Research
scaffold groups. Moreover, the Mg/Zn-co-doped group and Development Program of China (2023YFC2411300);
promoted angiogenesis and bone defect repair, with a National Natural Science Foundation of China
more pronounced effect observed when increasing Mg (82072412/92048205/ 52071277); Biomaterials and
doping. Compared to the Zn-doped group, the co-doped Regenerative Medicine Institute Cooperative Research
group exhibited significant advantages. Furthermore, Project by Shanghai Jiao Tong University School of Medicine
all scaffold groups exhibited favorable bone repair
outcomes in vivo, with the 10Mg10Zn and 15Mg10Zn (2022LHB08); Project of Shanghai Science and Technology
groups demonstrating particularly promising results. Commission (22015820100); China Postdoctoral Science
Taken together with the in vitro evaluations, the Foundation (2022M721685/2022M722121); and the
10Mg10Zn group may be a potential candidate for bone China Postdoctoral Science Foundation Special Grant
defect repair. Program (2023T160331).

Volume 10 Issue 6 (2024) 296 doi: 10.36922/ijb.4243