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International Journal of Bioprinting 3D-printed PCL-MNP multifunctional scaffolds

the Magnetherm can cause undue heating, even in the glass Funding
vial with the pure PCL scaffold, negatively affecting bone Sanjairaj Vijayavenkataraman was supported by the start-
cancer cells. The multi-functional PCL-MNP composite up funds from NYUAD. Susheem Kanwar acknowledges
scaffolds still require a significant amount of fine-tuning the NYUAD Global PhD Fellowship received to pursue his
to consistently achieve the necessary properties. While the graduate education.
results of this study are positive, the efficacy of the PCL-
MNP composite scaffolds in achieving its objectives can Conflict of interest
be further strengthened by testing their suitability for stem
cell differentiation and residual cancer cell death in animal Sanjairaj Vijayavenkataraman serves as the Editorial Board
models in future studies. Member of the journal but was not in any way involved
in the editorial and peer-review process conducted for this
5. Conclusion paper, directly or indirectly. Susheem Kanwar declares no
known competing financial interests or conflicts of interest.
In this work, we have examined the suitability of 3D-printed
PCL-MNP composite scaffolds in fulfilling both objectives Author contribution
of cancer management, i.e., resected tissue restoration
and tumor recurrence prevention, thus displaying their Conceptualization: Susheem Kanwar, Sanjairaj
Vijayavenkataraman
prospect. The multi-functional scaffolds were evaluated Data curation: Susheem Kanwar
for their magnetic, thermal, and mechanical properties, Formal analysis: Susheem Kanwar
as well as their biocompatibility. The mechanical strength Funding acquisition: Sanjairaj Vijayavenkataraman
and saturation magnetization of the scaffolds increased Investigation: Susheem Kanwar
with increasing MNP concentration, indicating enhanced Methodology: Susheem Kanwar, Sanjairaj
performance compared to pure PCL scaffolds. All scaffolds Vijayavenkataraman
were then tested for their biological viability and exhibited Project administration: Sanjairaj Vijayavenkataraman
statistically significant cell growth with increased cell Resources: Sanjairaj Vijayavenkataraman
proliferation commensurate with the concentration of Software: Susheem Kanwar
MNPs. This indicates that the PCL-MNP scaffolds are Supervision: Sanjairaj Vijayavenkataraman
suitable for bone TE. While all scaffolds were suitable Validation: Susheem Kanwar, Sanjairaj Vijayavenkataraman
for cell proliferation, only the scaffold with 50% MNP Visualization: Susheem Kanwar, Sanjairaj
displayed temperatures necessary for hyperthermia Vijayavenkataraman
treatment when placed under an AMF. When the PCL- Writing – original draft: Susheem Kanwar
50% MNP scaffolds were subjected to an external Writing – review & editing: Sanjairaj Vijayavenkataraman
magnetic field, a significant decrease in cancerous cells was
observed after 2 h. In conclusion, this work demonstrates Ethics approval and consent to participate
the fabrication of multi-functional bone scaffolds that Not applicable
satisfied four objectives: (i) patient-specific customization
through 3D printing, (ii) augmented mechanical strength Consent for publication
matching that of the native bone, (iii) enhanced stem
cell proliferation, and (iv) cancer cell necrosis under an Not applicable
external magnetic field.
Data availability
Acknowledgments The authors confirm that all data supporting the findings
This research was partially carried out using the Core of this study are available within the article.
Technology Platforms (CTP) resources at New York References
University Abu Dhabi (NYUAD). The authors would like
to thank Dr. Qiang Zhang (CTP, NYUAD) for his help with 1. Kanwar S, Al-Ketan O, Vijayavenkataraman S. A novel
the PPMS machine; Dr. Yao He (CTP, NYUAD) for his help method to design biomimetic, 3D printable stochastic
with TGA; Dr. James Weston (CTP, NYAD) for his help with scaffolds with controlled porosity for bone tissue
XRD; as well as Sharon Lee and the Trabolsi Lab (NYUAD) engineering. Mater Design. 2022;220:110857.
for their help with using the Magnetherm. The authors doi: 10.1016/j.matdes.2022.110857
would also like to extend their heartiest appreciation to Dr. 2. Liu JMH, Zhang J, Zhang X, et al. Transforming growth
Gopinathan and Dr. Kamil for their support. factor-beta 1 delivery from microporous scaffolds decreases

Volume 10 Issue 6 (2024) 403 doi: 10.36922/ijb.4538