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3D-Printed Artificial Vertebral Body
                                                                              C







           A                  B


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                              E











           Figure 9. Case 7. (A) Pre-operative X-ray and CT showing C1 and C2 tumor with pathological fracture and dislocation; (B) 3D imaging
           visually showing tumor in C1~2; (C) 3D imaging visually showing vertebrae planned to be resected and replaced with 3D-printed artificial
           vertebral body; (D) final titanium alloy implants; (E) post-operative X-ray showing reconstruction according to plan B, without the use of
           the 3D printed implant due to mismatching.

                        A                      B               C              D




















           Figure 10. Case 8. (A) Pre-operative X-ray showing fractured internal fixation rod and L1 artificial vertebral body subsidence; (B) 3D
           imaging visually showing the lesion; (C) 3D-printed artificial vertebral body and internal fixation system design; (D) post-operative X-ray
           showing spinal reconstruction using extendable artificial vertebra.

           4. Discussion                                       3D-printing  technology  has  shown  emerging  and
           A recent systematic review demonstrated that 3D printing   promising  application  in  personalized  spinal  implant
                                                                                      [13,14]
           technology  in  orthopedics  improves  operative  time,   and  reconstructive  surgery  .  Given  the  novelty  of
           blood  loss,  fluoroscopy  times,  bone  union  time,  pain,   3D-printed spinal implants, it is essential to conduct more
           accuracy, function, and without an increase in operative   prospective  studies  to  explore  its  specific  application
           complications .  Besides  being  used  for  preoperative   scope, experience, outcomes, and potential problems [15,16] .
                      [12]
           planning, surgery simulation, intraoperative navigation,   In this study, we utilized 3D-printed spinal implants
           patient  education,  and  doctor-patient  communication,   for reconstruction surgery of complex spinal tumors. Most

           90                          International Journal of Bioprinting (2022)–Volume 8, Issue 3
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