Page 337 - IJB-9-1

International Journal of Bioprinting Review on Hybrid Biomanufacturing Systems

A B C

D E

F G

Figure 5. (A) 3D Discovery (RegenHU, Switzerland). (B) Multi-material cell-laden hydrogel constructs deposited with the layer-by-layer UV curing
strategy , with permission from PLOS ONE (publisher). (C) Multi‑material cage constructs (top view) , with permission from MARY ANN LIEBERT
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INC (publisher) (D) BioFactory (RegenHU, Switzerland). (E) Hybrid printing system shows the inkjet print head and the electrospinning print
head , with permission from AMERICAN CHEMICAL SOCIETY (publisher). (F) Hybrid printing system combining the inkjet print head and the
[87]
electrospinning print head , with permission from IOP Publishing (publisher). (G) SEM image of hybrid scaffolds printed with extrusion-based 3D
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printing and electrospinning technologies , with permission from Elsevier (publisher).
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technologies, such as inkjet, pneumatic, thermoplastic can be applied as a wearable strain sensor to effectively
extrusion, and piston-driven disposition heads for the monitor and distinguish multifarious motions of a human
fabrication of 3D porous structures, as well as UV light, body.
photopolymerization, plasma pens, and nebulizers for Xu et al. (2012) developed a system combining inkjet
surface modification are all available on this biofabrication printing and electrospinning (Figure 5F) to fabricate
platform. Self-healing and ultrastrechable double-network nanofibrous viable tissues with enhanced mechanical and
hydrogel have been fabricated through BioFactory by biological properties for cartilage tissue engineering .
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combining cross-linked κ-carrageenan network and The electrospinning print head is used to generate a
polyacrylamide (PAAm) network (Figure 5E) . The polymeric fiber-based scaffold, and the inkjet print head
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printed 3D structure also presents remarkable sensitivity is designed to deposit cells onto the scaffold with a x-y-z
with a gauge factor of 0.63 at the strain of 1000%, which platform. The results revealed that both biological and

Volume 9 Issue 1 (2023) 329 https://doi.org/10.18063/ijb.v9i1.646