Page 80 - IJB-9-1

International Journal of Bioprinting

CLINICAL CASE STUDY
Feasibility of three-dimensional nasal imaging

and printing in producing customized nasal
masks for non-invasive ventilation in extremely

low birth weight infant: A pilot study

Antonio Martín-Gónzález , Begoña Morrás de la Torre , Elena Bergon-Sendin ,
1
3
2
Aaron Jesús Pérez-López , Alejandro Ferrando-Sánchez ,
1
2
Carmen Rosa Pallás-Alonso , María Teresa Moral-Pumarega *
3
3,
1 3D Printing Laboratory, Hospital Universitario 12 de Octubre, Madrid, Spain
2 Polytechnic University of Madrid, Madrid, Spain
3 Department of Neonatology, Hospital Universitario 12 de Octubre, SAMID Network, ISCIII, Madrid,
Spain
Abstract

Several studies have been conducted to investigate the feasibility of customized
nasal masks produced by three-dimensional (3D) facial imaging and printing for
continuous positive airway pressure in adults and in premature mannequin. In ad-
dition to replicating the entire process, we applied the customized nasal mask to a
*Corresponding author: premature patient who weighed less than 1,000 g. Facial scanning was performed.
María Teresa Moral-Pumarega
(mmoralp@salud.madrid.org) The study masks were manufactured using stereolithography with a 3D printer mod-
el Form3BL (FormLABS). Elastic 50 resin was used as the material. We verified the
Citation: Martín-Gónzález A, feasibility of the correct transmission of non-invasive ventilation and found that the
de la Torre BM, Bergon-Sendin E,
et al., 2023, Feasibility of three- mask improved the respiratory parameters and reduced the need for supplemental
dimensional nasal imaging and oxygen. The fraction of inspired oxygen (FiO ) was lowered from 45%, which was the
2
printing in producing customized requirement when the traditional mask is used, to almost 21% when the nasal mask
nasal masks for non-invasive
ventilation in extremely low birth was applied to the premature patient, who was either in incubator or in kangaroo
weight infant: A pilot study. Int J position. In view of these results, a clinical trial is being launched to evaluate the safe-
Bioprint, 9(1): 627. ty and efficacy of 3D-printed masks in extremely low birth weight (ELBW) infants. 3D
https://doi.org/10.18063/ijb.v9i1.627
printing provides an alternative for obtaining customized masks that may be more
Received: June 03, 2022 suitable for non-invasive ventilation in ELBW infants than traditional masks.
Accepted: September 01, 2022
Published Online: October 28,
2022
Keywords: Child health; Intensive care units; Neonatal; Neonatology; Technology
Copyright: © 2022 Author(s). and therapeutics
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution
and reproduction in any medium, 1. Introduction
provided the original work is
properly cited. Currently, most preterm infants are managed with non-invasive ventilation (NIV)
Publisher’s Note: Whioce in neonatal intensive care units. However, technical limitations of NIV are especially
Publishing remains neutral with apparent in infants who weigh less than 1,000 g (extremely low birth weight, ELBW). The
regard to jurisdictional claims in
published maps and institutional nasal masks available for use in NIV are often not adapted to the size and morphology
affiliations. of ELBW infants. This is an important limitation that leads to prolonged intubation or

Volume 9 Issue 1 (2023) 72 https://doi.org/10.18063/ijb.v9i1.627