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International Journal of Bioprinting                   3D-printed skin substitute accelerates wound healing in vivo



            A
























            B

























                               C                               D














            Figure 6. Immunohistochemistry staining was performed to assess the expression of CD31 on days 7 (A) and 14 (B) after the operation and quantification
            of capillary number was performed on days 7(C) and 14 (D). Scale bar = 100 μm. *P < 0.05; **P < 0.01; ***P < 0.001.

            has high biocompatibility and low immunogenicity, there   collapse, and the relatively long gelation time. But these
            are also some disadvantages, such as poor mechanical   could be improved by mixing it with other materials or
            properties, low printing resolution, susceptibility to   crosslinking agents .
                                                                              [15]


            Volume 9 Issue 2 (2023)                        402                      https://doi.org/10.18063/ijb.v9i2.674
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