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International Journal of Bioprinting 3D-printed skin substitute accelerates wound healing in vivo

biomaterial for 3D printing. dECM-GelMA-HAMA Availability of data
tissue-engineered skin substitute loaded with hADSCs
are prepared through 3D bioprinting technology. Not applicable.
It has stable scaffold structure and can accelerate References
wound healing, promote re-epithelialization, collagen
deposition and arrangement, attenuate inflammatory 1. Eke G, Mangir N, Hasirci N, et al., 2017, Development of a
response, and improve healing quality by promoting UV cross-linked biodegradable hydrogel containing adipose
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present study laid a pre-clinical research foundation
for the construction of tissue-engineered skin by 3D https://doi.org/10.1016/j.biomaterials.2017.03.021
bioprinting technology. 2. Weng T, Zhang W, Xia Y, et al., 2021, 3D bioprinting for skin
tissue engineering: Current status and perspectives. J Tissue
Acknowledgments Eng, 12: 20417314211028574.
The authors acknowledged the Fourth Medical Centre, https://doi.org/10.1177/20417314211028574
Chinese People’s Liberation Army General Hospital, 3. Goodarzi P, Falahzadeh K, Nematizadeh M, et al., 2018,
Central Medical Branch of PLA General Hospital and Tissue engineered skin substitutes. Adv Exp Med Biol,
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laboratory equipment provided.
https://doi.org/10.1007/5584_2018_226
Funding 4. Mu L, Zeng J, Huang Y, et al., 2021, Experimental study
on tissue engineered cartilage constructed by three-
This work was partially funded by National Natural Science dimensional bioprinted human adipose-derived stem cells
Foundation of China (82072176) and Postdoctoral Science combined with gelatin methacryloyl. Zhongguo Xiu Fu
Foundation of China (2020TQ0132). Chong Jian Wai Ke Za Zhi, 35: 896–903.

Conflict of interest https://doi.org/10.7507/1002-1892.202101049
The authors declare they have no competing interests. 5. Getova VE, van Dongen JA, Brouwer LA, et al., 2019, Adipose
tissue-derived ECM hydrogels and their use as 3D culture
Author contributions scaffold. Artif Cells Nanomed Biotechnol, 47: 1693–1701.
Conceptualization: Minliang Chen https://doi.org/10.1080/21691401.2019.1608215
Formal analysis: Huijuan Fu, Qiang Fu, Shiyi Li, Yi Yang 6. Chen Z, Zhang B, Shu J, et al., 2021, Human decellularized
Investigation: Huijuan Fu, Dequan Zhang, Zhaoyang Chen adipose matrix derived hydrogel assists mesenchymal
Methodology: Huijuan Fu, Dequan Zhang, Xuer Sun stem cells delivery and accelerates chronic wound healing.
Project administration: Huijuan Fu, Dequan Zhang, Jinshi J Biomed Mater Res A, 109: 1418–1428.
Zeng https://doi.org/10.1002/jbm.a.37133
Writing – original draft: Huijuan Fu 7. Kang MS, Kwon M, Lee SH, et al., 2022, 3D Printing of
Writing – review & editing: Huijuan Fu, Yi Yang, Shiyi Li skin equivalents with hair follicle structures and epidermal-
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Ethics approval and consent to participate hydrogels. Chem Asian J, 17: e202200620.
The animal experiments and surgical procedures https://doi.org/10.1002/asia.202200620
performed in this study were approved by the animal 8. Zhou ZQ, Chen Y, Chai M, et al., 2019, Adipose extracellular
ethics committee (Registration Number: 2022-X18-03) matrix promotes skin wound healing by inducing the
and performed following the code of practice for animal differentiation of adiposederived stem cells into fibroblasts.
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obtained from patients who underwent thigh or abdominal
liposuction in Department of Burn and Plastic Surgery, the https://doi.org/10.3892/ijmm.2018.4006
Fourth Medical Centre, Chinese People’s Liberation Army 9. Crapo PM, Gilbert TW, Badylak SF, 2011, An overview
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https://doi.org/10.1016/j.biomaterials.2011.01.057
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10. Pu W, Ren J, Chen Y, et al., 2020, Injectable human
Not applicable. decellularized adipose tissue hydrogel containing stem

Volume 9 Issue 2 (2023) 405 https://doi.org/10.18063/ijb.v9i2.674