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International Journal of Bioprinting 3D-printed vascularized biofunctional scaffold

Acknowledgments 2. Zhang YB, Liu XC, Zeng LD, et al., 2019, Polymer fiber
scaffolds for bone and cartilage tissue engineering. Adv
The authors thank the funding support from the General Funct Mater, 29(36):1903279.
program of NSFC (81972058) and Shanghai Key Clinical
Specialty Construction Project - Biomedical Materials https://doi.org/10.1002/adfm.201903279
(shslczdzk06701), Three-year Action Plan of Shenkang 3. Zheng CC, Attarilar S, Li K, et al., 2021, 3D-printed HA15-
Development Center (SHDC2020CR2019B), Huangpu loaded beta-tricalcium phosphate/poly (lactic-co-glycolic
District Industrial Support Fund (XK2020009), National acid) bone tissue scaffold promotes bone regeneration in
Key Science and Technology Infrastructure of Translational rabbit radial defects. Int J Bioprint, 7(1):100–111.
Medicine (Shanghai) Open Project (TMSZ-2020-207), https://doi.org/10.18063/ijb.v7i1.317
Shanghai Engineering Research Center of Innovative 4. Li Y, Xie KG, Wang C, et al., 2021, 3D printing of tricalcium
Orthopedic Instruments and Personalized Medicine phosphate/poly lactic-co-glycolic acid. Scaffolds loaded
(19DZ2250200), Shanghai Science and Technology with carfilzomib for treating critical-sized rabbit radial bone
Commission Yangtze River Delta Science and Technology defects. Int J Bioprint, 7(4):99–111.
Innovation Community Project (21002411200), and https://doi.org/10.18063/ijb.v7i4.405
Technical Standard Project of Shanghai Science and
Technology Commission (21DZ2201500). 5. Lin ZF, Wu MM, He HM, et al., 2019, 3D printing of
mechanically stable calcium-free alginate-based scaffolds
Conflict of interest with tunable surface charge to enable cell adhesion and
facile biofunctionalization. Adv Funct Mater, 29(9):1808439.
The authors declare no conflicts of interest. https://doi.org/10.1002/adfm.201808439

Author contributions 6. Groll J, Burdick JA, Cho DW, et al., 2019, A definition
of bioinks and their distinction from biomaterial inks.
Conceptualization: Bojun Cao, Yongqiang Hao Biofabrication, 11(1):013001.
Investigation: Bojun Cao, Jieming Lin, Jia Tan, Jiaxin Li, https://doi.org/10.1088/1758-5090/aaec52
Zhaoyang Ran, Liang Deng
Methodology: Yongqiang Hao, Jieming Lin 7. Zhang S, Chen J, Yu Y, et al., 2019, Accelerated bone
Supervision: Yongqiang Hao regenerative efficiency by regulating sequential release of
Writing – original draft: Bojun Cao BMP-2 and VEGF and synergism with sulfated chitosan.
ACS Biomater Sci Eng, 5(4):1944–1955.
Writing – review & editing: Bojun Cao, Yongqiang Hao
https://doi.org/10.1021/acsbiomaterials.8b01490
The manuscript is approved by all authors for
publication. 8. Kempen DH, Lu L, Heijink A, et al., 2009, Effect of
local sequential VEGF and BMP-2 delivery on ectopic
Ethics approval and consent to participate and orthotopic bone regeneration. Biomaterials, 30(14):
2816–2825.
All protocols involving experimental animals were https://doi.org/10.1016/j.biomaterials.2009.01.031
approved by the Animal Welfare Ethics Committee of the
Ninth People’s Hospital Affiliated to Shanghai Jiaotong 9. Geuze RE, Theyse LF, Kempen DH, et al., 2012, A differential
University School of Medicine (SH9H-2019-A717-1). effect of bone morphogenetic protein-2 and vascular
endothelial growth factor release timing on osteogenesis at
Consent for publication ectopic and orthotopic sites in a large-animal model. Tissue
Eng Part A, 18(19-20):2052–2062.
Not applicable. https://doi.org/10.1089/ten.TEA.2011.0560

Availability of data 10. Wei S, Xu P, Yao Z, et al., 2021, A composite hydrogel with
co-delivery of antimicrobial peptides and platelet-rich
Data will be made available on request. plasma to enhance healing of infected wounds in diabetes.
Acta Biomater, 124:205–218.
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Volume 9 Issue 3 (2023) 197 https://doi.org/10.18063/ijb.702