Page 174 - IJB-9-5

International Journal of Bioprinting

REVIEW ARTICLE
Functional materials of 3D bioprinting for

wound dressings and skin tissue engineering
applications: A review

Huan Fang 1,2† , Jie Xu 1,2† , Hailin Ma , Jiaqi Liu , Erpai Xing , Yuen Yee Cheng ,
3
1,2
1
1
Hong Wang *, Yi Nie *, Bo Pan *, Kedong Song *
2
4
1
5
1 State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering,
Dalian University of Technology, Dalian 116024, Liaoning, China
2 Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, Henan, China
3 Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology
Sydney, NSW 2007, Australia
4 Department of Orthopaedics, Dalian Municipal Central Hospital Affiliated of Dalian University of
Technology, Dalian 116033, China
5 Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023,
China
(This article belongs to the Special Issue List: Advances in 3D bioprinting for regenerative medicine and drug
screening)
† These authors contributed equally
to this work. Abstract
*Corresponding authors: The skin plays an important role in vitamin D synthesis, humoral balance, temperature
Kedong Song
(Kedongsong@dlut.edu.cn) regulation, and waste excretion. Due to the complexity of the skin, fluids loss, bacterial
Hong Wang infection, and other life-threatening secondary complications caused by skin
(whwl@dlut.edu.cn) defects often lead to the damage of skin functions. 3D bioprinting technology, as a
Yi Nie customized and precise biomanufacturing platform, can manufacture dressings and
(ynie@ipe.ac.cn) tissue engineering scaffolds that accurately simulate tissue structure, which is more
Bo Pan conducive to wound healing. In recent years, with the development of emerging
(dmupanbo@hotmail.com) technologies, an increasing number of 3D-bioprinted wound dressings and skin
Citation: Fang H, Xu J, Ma H, et al., tissue engineering scaffolds with multiple functions, such as antibacterial, anti-
2023, Functional materials of 3D inflammatory, antioxidant, hemostatic, and antitumor properties, have significantly
bioprinting for wound dressings and
skin tissue engineering applications: improved wound healing and skin treatment. In this article, we review the process
A review. Int J Bioprint, 9(5): 757. of wound healing and summarize the classification of 3D bioprinting technology.
https://doi.org/10.18063/ijb.757 Following this, we shift our focus on the functional materials for wound dressing and
Received: August 10, 2022 skin tissue engineering, and also highlight the research progress and development
Accepted: January 31, 2023 direction of 3D-bioprinted multifunctional wound healing materials.
Published Online: May 18, 2023
Copyright: © 2023 Author(s).
This is an Open Access article Keywords: Functional materials; Wound healing; 3D bioprinting; Dressing; Skin
distributed under the terms of the tissue engineering
Creative Commons Attribution
License, permitting distribution
and reproduction in any medium,
provided the original work is
properly cited. 1. Introduction
Publisher’s Note: Whioce The skin is the largest integumentary organ in the human body, accounting for
Publishing remains neutral with
[1]
regard to jurisdictional claims in approximately 15% of the body weight . The skin has a multilayered structure, divided
published maps and institutional into epidermis, dermis, and subcutaneous layer, which is an important barrier for
affiliations.

Volume 9 Issue 5 (2023) 166 https://doi.org/10.18063/ijb.757