Page 409 - IJB-9-5

International Journal of Bioprinting

RESEARCH ARTICLE
3D-printed biodegradable magnesium alloy

scaffolds with zoledronic acid-loaded ceramic
composite coating promote osteoporotic bone

defect repair

Zhaoyang Ran 1,2† , Yan Wang , Jiaxin Li , Wenyu Xu , Jia Tan , Bojun Cao ,
1,2
4†
1,2
3†
5
Dinghao Luo , Yiwen Ding , Junxiang Wu , Lei Wang , Kai Xie , Liang Deng ,
1,2
1,2
1,2
1,2
1,2
5
Penghuai Fu *, Xiaoying Sun *, Liyi Shi , Yongqiang Hao *
3
5
1,2
3
1 Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai
Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011,
China
2 Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized
Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine,
Shanghai 200011, China
3 Nano-Science & Technology Center, College of Sciences, Shanghai University, Shanghai 200444,
China
4 Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin
150001, China
† These authors contributed equally 5 National Engineering Research Center of Light Alloy Net Forming & State Key Laboratory of Metal
to this work. Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China
*Corresponding authors:
Yongqiang Hao
(hyq_9hospital@hotmail.com)
Xiaoying Sun Abstract
(xysun@shu.edu.cn)
Penghuai Fu Osteoporotic fracture is one of the most serious complications of osteoporosis. Most
(fph112sjtu@sjtu.edu.cn) fracture sites have bone defects, and restoring the balance between local osteogenesis
Citation: Ran Z, Wang Y, Li J, et al., and bone destruction is difficult during the repair of osteoporotic bone defects. In
2023, 3D-printed biodegradable this study, we successfully fabricated three-dimensional (3D)-printed biodegradable
magnesium alloy scaffolds with
zoledronic acid-loaded ceramic magnesium alloy (Mg-Nd-Zn-Zr) scaffolds and prepared a zoledronic acid-loaded
composite coating promote ceramic composite coating on the surface of the scaffolds. The osteogenic effect of
osteoporotic bone defect repair. Mg and the osteoclast inhibition effect of zoledronic acid were combined to promote
Int J Bioprint, 9(5): 769.
https://doi.org/10.18063/ijb.769 osteoporotic bone defect repair. In vitro degradation and drug release experiments
showed that the coating significantly reduced the degradation rate of 3D-printed
Received: March 19, 2023 Mg alloy scaffolds and achieved a slow release of loaded drugs. The degradation
Accepted: April 27, 2023
Published Online: June 7, 2023 products of drug-loaded coating scaffolds can promote osteogenic differentiation of
bone marrow mesenchymal stem cells as well as inhibit the formation of osteoclasts
Copyright: © 2023 Author(s).
This is an Open Access article and the bone resorption by regulating the expression of related genes. Compared
distributed under the terms of the with the uncoated scaffolds, the drug-coated scaffolds degraded at a slower rate,
Creative Commons Attribution and more new bone grew into these scaffolds. The healing rate and quality of the
License, permitting distribution,
and reproduction in any medium, osteoporotic bone defects significantly improved in the drug-coated scaffold group.
provided the original work is This study provides a new method for theoretical research and clinical treatment
properly cited. using functional materials for repairing osteoporotic bone defects.
Publisher’s Note: Whioce
Publishing remains neutral with
regard to jurisdictional claims in Keywords: Osteoporotic fractures; Magnesium alloys; 3D printing; Bone defects
published maps and institutional repair; Surface modification
affiliations.

Volume 9 Issue 5 (2023) 401 https://doi.org/10.18063/ijb.769