Page 444 - IJB-9-6

International

Journal of Bioprinting

REVIEW ARTICLE
Multiscale 3D bioprinting for the recapitulation

of lung tissue

Pengbei Fan , Fanli Jin , Yanqin Qin , Yuanyuan Wu , Qingzhen Yang *,
1,2
1,2
1,2
1,2
3,4
Han Liu *, and Jiansheng Li *
1,2
1,2
1 Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Academy of Chinese Medical
Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, P.R. China
2 Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by
Henan Province and Education Ministry of China, Zhengzhou, Henan 450046, P.R. China
3
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life
Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, P.R. China
4 Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an,
Shaanxi 710049, P.R. China
(This article belongs to the Special Issue: Nano-enabled 3D Bioprinting for Various Tissue Engineering)

Abstract

Lung tissue engineering (LTE) has gained significant attention as a highly promising
and innovative strategy to tackle the formidable obstacles posed by lung-related
diseases and the lack of compatible donor organs availability. In the realm of
groundbreaking advancements in tissue engineering (TE), one particular technology
*Corresponding authors:
Jiansheng Li that has emerged as a game-changer is three-dimensional (3D) bioprinting. It
(li_js8@163.com) distinguishes itself by offering a potent and versatile approach to constructing
Han Liu intricate structures while opening up new horizons for TE and regenerative medicine
(liuhan1969@hactcm.edu.cn) (RM). This review focuses on the application of multiscale 3D bioprinting techniques
Qingzhen Yang in LTE and the reconstitution of lung tissue in vitro. We analyzed the key aspects
(qzyang@mail.xjtu.edu.cn) such as bioink formulations and printing strategies utilized from macroscale 3D
bioprinting to micro/nanoscale 3D bioprinting. Additionally, we evaluated the
Citation: Fan P, Jin F, Qin Y, et al.,
2023, Multiscale 3D bioprinting for potential of multiscale bioprinting to replicate the complex architecture of the
the recapitulation of lung tissue. lung, ranging from macrostructures to micro/nanoscale features. We discussed the
Int J Bioprint, 9(6): 1166. challenges and future directions in biofabrication approaches for LTE. Furthermore,
https://doi.org/10.36922/ijb.1166
we highlight the current progress and future perspectives in tissue reconstitution of
Received: June 27, 2023 lung in vitro, considering factors such as cell source, functionalization, and integration
Accepted: August 8, 2023
Published Online: September 4, of physiological cues. Overall, multiscale 3D bioprinting offers exciting possibilities
2023 for the development of functional lung tissues, enabling disease modeling, new
Copyright: © 2023 Author(s). drug screening, and personalized regenerative therapies.
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution Keywords: Multiscale 3D bioprinting; Lung tissue engineering; Biofabrication; Tis-
License, permitting distribution, sue reconstitution in vitro
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional Lung tissue engineering (LTE) represents a dynamically progressing domain, with
affiliations. continuous research endeavors directed toward surmounting the obstacles linked to the

Volume 9 Issue 6 (2023) 436 https://doi.org/10.36922/ijb.1166