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International Journal of Bioprinting 3D bioprinting for translational toxicology

Table 2. Applications of common three-dimensional printing techniques in tissue modeling, organ-on-a-chip fabrication, and
biosensor production
Method Target Materials Cell types Applications
EBB Three-dimensional scaffolds Hyaluronic acid; chitosan MG63 Bone defect repair and bone tissue regeneration
for bone tissue engineering research 122
In vitro air-blood barrier Matrigel A549; In vitro models for lung disease research and
model EA.hy926 drug testing 17
Printable POC biosensors Organoxilane polymer, __ Manufacturing stable biosensors for early disease
AuNR, protein A, IgG diagnosis 79
Human skin tissue Collagen HaCaT; In vitro models for skin grafts and wound healing
HFF-1 research 123
Inkjet Multi-cell heterogeneous SA; collagen hAFSCs; Constructing complex tissue models with
tissue constructs dSMCs; multiple cell types for tissue engineering
bECs research 124
Liver-on-a-chip SA HepG2; Drug metabolism and diffusion experiments to
U251 imitate in vivo situations 79
Hybrid nasal cartilage with GelMA; PEGDMA Chondrocytes; Electronic olfaction 125
electronic olfaction ADSCs; HUVECs
SLA Cell loading model PEGDA; GelMA NIH 3T3 Cell patterning in tissue engineering and
bioengineering 126
Vascularized bonemimetic Gelatin; GelMA HUVEC; Bone tissue engineering, promoting osteogenesis
hydrogel C3H10T1/2 and angiogenesis 127
Hydrogel scaffolds PAA __ Develop an ultrasensitive fiber-optic pH sensor 128
Engineered biofilms with PEGDa bioresins Escherichia coli; Uranium element detection 82
bacteria Caulobacter
crescentus
LAB Microneedles PMMA __ Transdermal delivery of chemotherapeutic drugs
via microneedles 129
Skin-on-a-chip Collagen NIH3T3; Constructing skin-like organs with functions 91
HaCaT
DLP Human iPSC-derived hepatic GelMA; GMHA hiPSC-HPCs; Drug screening and disease modeling 86
model HUVECs;vADSCs
Liver lobule microtissue HAMA hydrogel, HepG2 Aflatoxin B1 detection 130
biosensor MWCNTs
Lung-on-a-chip Resin (BV-007) Calu-3 Respiratory toxicological testing and pulmonary
drug delivery studies 131
Patterned cell-laden heart and GelMA; HdECM hiPSC-CMs; Serve as potential physiologically-relevant living
liver tissue constructs hiPSC-Heps human tissue platforms 132
SLS Three-dimensional Ca-P/PHBV; CHAp/PLLA SaOS-2 Bone tissue engineering, constructing
nanocomposite scaffolds for biomimetic bone scaffolds 93
bone tissue engineering
Cell density sensor Metallic powder; __ Monitoring cell density 133
polyamide; PVC
Suspended Multiple-layered vascular VdECM; HUVECs; In vitro modeling of the initiation of arterial
bioprinting models Pluronic F127 HCASMCs disorders 134
Full-size model of the heart Gelatin microparticles; SA __ Surgical simulation and training 135
Abbreviations: ADSCs, adipose-derived stem cells; AuNR, gold nanorods; bECs, bovine aortic endothelial cells; Ca-P/PHBV, calcium phosphate/
poly(hydroxybutyrate-co-hydroxyvalerate); CHAp/PLLA, carbonated hydroxyapatite/poly(L-lactic acid); DLP, digital light processing; dSMCs, canine
smooth muscle cells; E. coli, Escherichia coli; EBB, extrusion-based bioprinting; GelMA, gelatin methacrylate; GMHA, glycidyl methacrylate hyaluronic
acid; hAFSCs, human amniotic fluid-derived stem cells; HAMA, methylacylated hyaluronic acid; HCASMCs, human coronary artery smooth muscle
cells; HdECM, heart decellularized extracellular matrix; hiPSC-Heps, human induced pluripotent stem cell-derived hepatocytes; hiPSC-CMs, human
induced pluripotent stem cell-derived cardiomyocytes; hiPSC-HPCs, human induced pluripotent stem cell-derived hepatic progenitor cells; HUVECs,
human umbilical vein endothelial cells; IgG, immunoglobulin G; LAB, laser-assisted bioprinting; MWCNTs, multi-walled carbon nanotubes; PAA,
poly(acrylic acid); PEGDA, polyethylene glycol diacrylate; PEGDMA, polyethylene glycol dimethacrylate; PMMA, polymethylmethacrylate; PVC,
polyvinyl chloride; SA, sodium alginate; SLA, stereolithography; SLS, selective laser sintering; VdECM, vascular decellularized extracellular matrix.

Volume 11 Issue 4 (2025) 108 doi: 10.36922/IJB025210209