Page 14 - IMO-1-1

Innovative Medicines & Omics Antioxidant nanomedicines for therapies

A B

C

Figure 6. Trehalose-based nanomedicine for atherosclerosis management. (A) Synthetic procedure of trehalose-based nanomedicine. (B) Targeting
106
mechanism of nanomedicine. (C) Anti-atherosclerotic mechanism of nanomedicine. Reproduced with permission from Wu et al. Copyright © 2022,

American Chemical Society.
have been used for treating peripheral arterial disease. injury, and intraluminal thrombus formation. This
116
125
However, their therapeutic efficacies are unsatisfying due disease is asymptomatic during development, but once
to their low bioavailability. 117 the bloodstream breaks through a weak area of aortic
Jung et al. have fabricated a boronated maltodextrin aneurysm, the patient will die soon. The mortality
126
nanoparticle that can react with H O at the ischemic sites of aortic aneurysm is over 90%. At present, only
2
2
of artery to mitigate inflammation. Mouse model of surgical interventions including open surgery and
118
hindlimb ischemia also demonstrates a desirable efficacy endovascular aneurysm repair are the available choices
of the nanomedicine. Benefiting from the development for aortic aneurysm management. 127,128 However, surgical
of metal-polyphenol networks. 119-121 Duan et al. prepared interventions suffer from pathogenic infection, endoleak,
a metal-polyphenol capsule through the coordination secondary aneurysm rupture, etc., compromising patient
127
between Cu and epigallocatechin-3-gallate (EGCG), compliance and long-term safety. The development of
2+
and used the nanomedicine for peripheral artery disease aortic aneurysm is closely associated with aortic oxidative
treatment. EGCG is an active component of green tea stress and inflammation, resulting in vascular endothelial
122
129-131
that can scavenge ROS efficiently, while Cu component injury. Therefore, it is expected that ROS-scavenging
123
can promote angiogenesis by favoring the secretion in aneurysmal region may facilitate the regulation of aortic
of vascular endothelial growth factor (VEGF). The wall microenvironment for the effective therapy of such a
124
132
synergistic action of two components in the nanoparticle lethal aortic disease.
enables the effective treatment of peripheral artery disease, Recently, Lin et al. have prepared a multifunctional
as demonstrated by a hindlimb ischemia model. nanomicelle for antioxidant treatment of abdominal aortic
133
aneurysm (Figure 7). The nanomicelle was assembled from
3.5. Aortic aneurysm treatment a designed amphiphilic conjugate. In the conjugate, cyanuric
Aortic aneurysm is a degenerative pathology in aorta, chloride is a skeleton to conjugate different molecules,
it is not an aortic tumor but an enlargement in aorta, 4-hydroxyphenylboronic acid pinacol ester is a redox-
accompanied by aortic wall thinning, vascular endothelial active molecule enabling ROS-responsive degradability. TP

Volume 1 Issue 1 (2024) 8 doi: 10.36922/imo.2527