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Innovative Medicines & Omics Antioxidant nanomedicines for therapies

Table 1. Summary of representative antioxidant nanomedicines for the treatment of cardiovascular diseases
Antioxidant Reaction type Disease References
Curcumin/resveratrol-loading PGMA nanoparticle Non-catalytic Myocardial ischemia-reperfusion injury 61
SOD-loading MOF nanoparticle Catalytic Myocardial ischemia-reperfusion injury 62
Melanin nanoparticle Non-catalytic Myocardial ischemia-reperfusion injury 64
Allomelanin nanoparticle Non-catalytic Myocardial ischemia-reperfusion injury 66
Fullerene Catalytic Myocardial ischemia-reperfusion injury 67
CeO nanoparticle Catalytic Myocardial ischemia-reperfusion injury 69
2
Copper-deposited CeO nanoparticle Catalytic Myocardial ischemia-reperfusion injury 68
2
Vanillyl alcohol-loading nanoparticle Non-catalytic Chemodrug-induced cardiomyopathy 76
Magnesium hexacyanoferrate nanoparticle Catalytic Chemodrug-induced cardiomyopathy 77
TP and phenylboronic acid pinacol ester-loading Multiple Atherosclerosis 95
nanoparticle
Hyaluronic acid-stabilized CeO nanoparticle Catalytic Atherosclerosis 96
2
Prussian blue nanoparticle Catalytic Atherosclerosis 99
Pt nanoparticle-loading nanoliposome Catalytic Atherosclerosis 100
L-arginine-loading trehalose nanoparticle Non-catalytic Atherosclerosis 106
PdH nanoparticle Multiple Atherosclerosis 111
Phenyl boronic ester-loading maltodextrin nanoparticle Noncatalytic Peripheral arterial disease 118
Cu-EGCG capsule Non-catalytic Peripheral arterial disease 122
TP-loading nanomicelle Catalytic Aortic aneurysm 133
TP-loading nanoparticle Catalytic Thrombosis 147
Polydopamine-coated Fe O nanoparticle Non-catalytic Thrombosis 148
3
4
Protocatechualdehyde-loading phenylboronic acid Non-catalytic Thrombosis and myocardial ischemia-reperfusion injury 150
nanoparticle
Abbreviation: SOD: Superoxide dismutase; MOF: Metal-organic framework; PGMA: Prepared poly (glycidyl methacrylate);
EGCG: Epigallocatechin-3-gallate; TP: Tempol

safranin-O staining of joint demonstrated the recovery SOD and catalase-like activities, in which each MnTCPP
+
of cartilage structure. Followed the work, Xu et al. also acts as a catalytic unit for enabling biomimetic catalysis
2+
prepared CeO -loading MSNs with MnO coating for and ROS scavenging capacity. Zn can counteract negative
2
2
+
concurrent ROS-scavenging and O generation. 164 charge of peripheral benzoyloxy groups of MnTCPP ,
2
Inspired from coordination chemistry, some antioxidant elevating the redox potential of Mn center, thereby favoring
catalytic antioxidation reactions. In arthritic region, the
nanocatalysts were constructed by coordination between biomimetic nanocatalyst can scavenge excessive ROS
transition metal ions and organic ligands, of which the and mitigate inflammation. Based on the unique catalytic
organic ligands can regulate the catalytic kinetics and antioxidative properties of Mn porphyrins, 167-169 we also
thermodynamics of metal ions, thus regulating the catalytic constructed an MSN-based nanomedicine for in situ
efficiency. Guo et al. prepared a metal-polyphenol network synthesis of Mn porphyrin in arthritic regions. 170
by coordination between Fe and tannic acid, with catalytic
3+
antioxidative activity for rheumatoid arthritis treatment. 4.2. Osteoarthritis treatment
165
Our research group recently constructed a biomimetic Osteoarthritis is the most prevalent form of arthritis.
171
two-dimensional nanocatalyst, by coordination between Different from rheumatoid arthritis, osteoarthritis is a
III
Zn and a typical Mn porphyrin, Mn meso-tetrakis(4- degenerative disease, characteristic of cartilage erosion and
2+
carboxyphenyl)porphyrin (MnTCPP ) (Figure 10). In chronic low-grade synovium inflammation. Rheumatoid
166
+
172
+
the nanomaterial, the ordered assembly of MnTCPP forms arthritis often affects small joints, such as the hands and
a periodic and symmetric structure. As the coordination feet, while in osteoarthritis, the most damaged joints are
environment of Mn center in each Mn porphyrin is similar to the weight-bearing knees and spines. The aging-related
173
those of natural SOD and catalase, the nanomaterial exhibits ROS production is a key pathogenic factor of osteoarthritis,
Volume 1 Issue 1 (2024) 12 doi: 10.36922/imo.2527