Page 15 - IMO-1-1
P. 15
Innovative Medicines & Omics Antioxidant nanomedicines for therapies
A
B
Figure 7. Schematic illustration for the synthesis of nanomedicine (A) and its mechanism for abdominal aortic aneurysm treatment (B). Reproduced with
permission from Lin et al. . Copyright © 2022, Wiley-VCH.
133
is a molecular antioxidant with catalytic ROS-scavenging activity of TP and immunosuppressive property of
property. PEG was also grafted to improve colloidal rapamycin, the nanomicelle can largely alleviate oxidative
134
stability. The amphiphilic conjugate can self-assemble into stress and inflammation in aneurysmal tissue, achieving
nanomicelle in an aqueous phase to load immunosuppressant efficient treatment of abdominal aortic aneurysm.
rapamycin. After intravenous administration, the Aortic dissection is a more lethal aortic disease than
nanomicelle will accumulate in the aneurysmal tissue aortic aneurysm. Till now, no effective therapeutic
135
passively, subsequently entering neutrophils, macrophages, approach has been developed to prevent the progression
and vascular smooth muscle cells. Due to the antioxidative of this disease. As the pathological mechanism of aortic
136
Volume 1 Issue 1 (2024) 9 doi: 10.36922/imo.2527
