Page 26 - IMO-1-1

Innovative Medicines & Omics Antioxidant nanomedicines for therapies

Figure 15. Schematic illustration for the synthesis of polypeptide-templated nanocatalyst and its application in antioxidant therapy of ischemic stroke.
Reproduced with permission from Wang et al. Copyright © 2023, Wiley-VCH.

The utilization of the single-atom catalysis concept can not only alleviate neuroinflammation, but also repair
in biomedicine has recently been exemplified by the the damaged BBB after brain trauma, favoring the recovery
construction of nanocatalysts with atomically dispersed of brain.
metal sites, for achieving maximum atomic utilization of The development of antioxidant nanomedicines
metals during catalytic ROS regulation so as to enhance
256
the therapeutic effect. Liu et al. demonstrated that the provides new strategies for treating brain diseases
Au cluster after single-atom substitution is efficient to (Table 3). However, future efforts are still needed such
25
alleviate neuroinflammation in a model of traumatic brain as comprehensive evaluations on long-term safety of
injury. Zhang et al. constructed a series of single-atom nanoparticles in the highly sensitive brain region.
257
nanocatalysts, RhN , VN , and Fe-Cu-N with M-N sites 6. Kidney disease treatment
4
4
6
4
that can mitigate oxidative stress and neuroinflammation
after brain trauma (Figure 16). These nanocatalysts The kidney is a key organ of urinary system that filters
258
present higher catalytic activities than natural enzymes, impurities from the blood, maintains fluid and electrolyte
showing the superiority of single-atom catalysis. Recently, balance, and produces urine excreted through urethra.
Huang et al. also prepared a single-atom Mn nanocatalyst Oxidative stress is a pathogenic factor for various renal
with a high ROS-scavenging efficiency. The nanocatalyst dysfunctions, such as acute kidney injury and chronic
259
Volume 1 Issue 1 (2024) 20 doi: 10.36922/imo.2527