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Innovative Medicines & Omics Antioxidant nanomedicines for therapies

in which the two components can scavenge ROS secondary MRSA infection. Recently, we also fabricated
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synergistically. The nanoparticle was also demonstrated zinc hexacyanoferrate nanoparticles for treating bacterial
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to be capable of alleviating inflammatory response in a pneumonia, which can mimic the catalytic activities
lipopolysaccharide-induced lung inflammation model. of both SOD and catalase to scavenge ROS efficiently,
alleviating inflammation. In addition, the nanoparticles
To achieve concurrent anti-inflammation and also present broad-spectrum antibacterial property
pathogen eradication, the antioxidant nanomedicines against various pathogenic bacteria, due to the release of
should have antiviral/antibacterial property. Li et al. antibacterial Zn cations. The synergistic actions of anti-
2+
prepared tea nanodots composed of eight kinds of tea bacteria and anti-inflammation result in a high therapeutic
catechins extracted from black tea (Figure 20). The efficacy against bacterial pneumonia.
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tea nanodots can eradicate H1N1 influenza virus by
blocking neuraminidase active site, kill methicillin- 7.2. Pulmonary fibrosis treatment
resistant Staphylococcus aureus (MRSA) by inhibiting Pulmonary fibrosis is an idiopathic, intractable, and life-
amino acid metabolism, and alleviate cytokine storms by threatening lung disease characterized by progressive
ROS scavenging and anti-inflammation. The nanodots scarring of lung parenchyma. It is initiated by multiple
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were combined with another herbal medicine luteolin external factors that trigger ROS overproduction in
in aerosol and administrated though respiratory tract, alveolar epithelial cells, leading to severe oxidative damage
presenting high efficacy in treating lethal H1N1-MRSA of pulmonary alveoli. Subsequently, neutrophils are
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pneumonia triggered by H1N1 infection-induced severe recruited that produce additional ROS to activate M1

Figure 20. Schematic illustration for treating lethal H1N1-MRSA pneumonia using multifunctional tea nanodots. Reproduced with permission from Li
et al. Copyright © 2021, Elsevier.
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Volume 1 Issue 1 (2024) 25 doi: 10.36922/imo.2527