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INNOSC Theranostics and
Pharmacological Sciences Plants immunoactivity: In silico study

Figure 1. Diagrammatic representation of the protein-protein interaction (with a confidence score of 0.7 and above) between the different bioactives’
immune targets. Round globes indicate each bioactive immune target; the lines show their interactions with one another; round globes without lines
indicate a confidence interaction score lower than 0.

Furthermore, a PPi interaction was also carried out heat-shock protein 90-alpha (HSP90AA1), growth factor
on the multiple myeloma-related targets of the bioactives, receptor bound Protein 2 (GRB2), phosphatidylinositol
leading to the identification of hub targets. This network 3-kinase regulatory subunit alpha (PIK3R1), interleukin 2
comprised 65 nodes and 554 edges, demonstrating a PPi (IL2), and interleukin 6 (IL6).
enrichment P-value of <1.0e-16. Among these hub targets,
key players emerged, including mitogen-activated protein 3.8. Functional enrichment analysis of the active
kinase 3 (MAPK3), signal transducer and activator of phytocompounds immune targets
transcription 3 (STAT3), alpha serine-threonine protein GO enrichment analysis was used to investigate the
kinase 1 (AKT1), Harvey rat sarcoma virus (HRAS), functional roles of the immunomodulatory-associated

Volume 7 Issue 1 (2024) 7 https://doi.org/10.36922/itps.1076