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INNOSC Theranostics and
Pharmacological Sciences Plants immunoactivity: In silico study

Table 2. Depicting all of the bioactives' immune gene targets as well as the immune pathways in which they are involved
KEGG ID IMMUNE PATHWAY GENE (NO) GENE INVOLVED FROM THE LIST
hsa04622 RIG-I-like receptor signaling 23 NFKBIA, NFKB1, MAPK14, TRAF2, RIPK1, IFNA1, CASP10, CXCL10, TRIM25,
pathway CASP8, ATG5, CHUK, IFNA2, IFNB1, MAPK8, RELA, CYLD, MAPK9, TNF,
IKBKB, TRAF6, TRAF3, IKBKG
hsa04666 Fc gamma R-mediated phagocytosis 20 MAPK1, PIK3R2, RAF1, MAPK3, PIK3CA, FCGR2A, PIK3CB, ARPC5, MAP2K1,
SPHK1, GAB2, FCGR3A, SYK, PIK3CD, INPP5D, PRKCA, PTPRC, PIK3R1, HCK,
AKT1
hsa04670 Leukocyte transendothelial 18 PIK3R2, MAPK14, PIK3CA, ICAM1, PIK3CB, PTPN11, PTK2, CTNNB1, ACTB,
migration MMP9, PIK3CD, CXCL12, ITGB1, PTK2B, ITGB2, CXCR4, PRKCA, PIK3R1
hsa04611 Platelet activation 16 MAPK1, PIK3R2, MAPK14, MAPK3, PIK3CA, FCGR2A, PIK3CB, ACTB, PIK3CG,
SYK, PIK3CD, ITGB1, PIK3R1, AKT1, ITGB3, BTK
hsa04640 Hematopoietic cell lineage 14 CD22, EPOR, KITLG, IL4, IL1A, IL1B, CSF1R, KIT, CD14, CD1D, IL6, TNF, CD19,
ITGB3
hsa04658 Th1 and Th2 cell differentiation 27 MAPK1, IL2RB, NFKBIA, NFKB1, IL2, IFNG, MAPK14, IL4, MAPK3, NOTCH1,
STAT5B, IL13, FOS, STAT5A, JAK1, STAT1, CD247, CHUK, JUN, IL2RG, JAK2,
MAPK8, RUNX3, RELA, MAPK9, IKBKB, IKBKG
hsa04664 Fc epsilon RI signaling pathway 27 MAPK1, PIK3R2, MAPK14, IL4, RAF1, KRAS, MAPK3, PIK3CA, PIK3CB,
MAP2K1, IL13, PDPK1, GAB2, NRAS, SYK, PIK3CD, GRB2, MAPK8, MAP2K7,
MAPK9, TNF, INPP5D, HRAS, PRKCA, PIK3R1, AKT1, BTK
hsa04650 Natural killer cell mediated 33 MAPK1, PIK3R2, IFNG, KLRK1, TNFSF10, RAF1, KRAS, MAPK3, PIK3CA,
cytotoxicity ICAM1, IFNAR1, IFNA1, PIK3CB, MAP2K1, PTPN11, CD247, FCGR3A, NRAS,
NCR2, SYK, PIK3CD, IFNA2, IFNB1, GRB2, PTK2B, ITGB2, PTPN6, TNF, HLAB,
HRAS, PRKCA, MICA, PIK3R1
hsa04062 Chemokine signaling pathway 39 MAPK1, NFKBIA, PIK3R2, CCL2, NFKB1, CCR7, RAF1, KRAS, MAPK3, PIK3CA,
STAT3, PIK3CB, CCR2, STAT5B, MAP2K1, CXCL10, CXCL11, CCR4, PTK2,
GPR29, PIK3CG, STAT1, NRAS, CHUK, CXCR3, PIK3CD, JAK2, GRB2, CXCL12,
PTK2B, RELA, CXCR4, HRAS, PIK3R1, IKBKB, HCK, AKT1, CCL5, IKBKG
hsa04662 B cell receptor signaling pathway 30 CD22, MAPK1, NFKBIA, PIK3R2, NFKB1, RAF1, KRAS, MAPK3, PIK3CA,
PIK3CB, MAP2K1, FOS, MALT1, NRAS, CHUK, BCL10, JUN, SYK, PIK3CD,
GRB2, RELA, PTPN6, INPP5D, HRAS, PIK3R1, IKBKB, CD19, AKT1, BTK, IKBKG
hsa04657 IL-17 signaling pathway 34 MAPK1, NFKBIA, CCL2, NFKB1, IFNG, MAPK14, IL4, TRAF2, MAPK3, IL1B,
HSP90B1, IL13, CXCL10, FOS, MAPK7, HSP90AA1, IL17A, CASP8, PTGS2,
S100A9, CHUK, JUN, MMP9, LCN2, MAPK8, RELA, IL6, MAPK9, TNF, IKBKB,
TRAF6, TRAF3, TNFAIP3, IKBKG
hsa04659 Th17 cell differentiation 38 MAPK1, IL2RB, NFKBIA, TGFB1, NFKB1, IL2, IFNG, MAPK14, IL4, AHR,
MAPK3, IL1B, IL21, STAT3, STAT5B, FOS, SMAD3, HSP90AA1, STAT5A, JAK1,
IL17A, STAT1, MTOR, CD247, CHUK, JUN, IL2RG, IRF4, IL6ST, JAK2, MAPK8,
RELA, IL6, MAPK9, IKBKB, HIF1A, IL22, IKBKG
hsa04620 Toll-like receptor signaling pathway 47 MAPK1, NFKBIA, PIK3R2, NFKB1, MAPK14, RIPK1, MAPK3, MAP3K8, IL1B,
PIK3CA, CD80, IFNAR1, CTSK, IFNA1, PIK3CB, TLR3, MAP2K1, CD14, CXCL10,
FOS, CXCL11, CD86, CASP8, STAT1, IRAK1, CHUK, JUN, CD40, TLR4, PIK3CD,
IFNA2, IFNB1, SPP1, MAPK8, MAP2K7, RELA, IL6, MAPK9, TNF, MYD88,
PIK3R1, IKBKB, TRAF6, AKT1, TRAF3, CCL5, IKBKG
hsa04660 T cell receptor signaling pathway 43 MAPK1, NFKBIA, PIK3R2, NFKB1, IL2, IFNG, MAPK14, IL4, RAF1, KRAS,
MAPK3, MAP3K8, PIK3CA, PIK3CB, MAP2K1, CTLA4, FOS, MALT1, CD28,
PDCD1, PDPK1, CD247, NRAS, CHUK, BCL10, JUN, PIK3CD, GRB2, MAPK8,
MAP2K7, RELA, PTPN6, MAPK9, TNF, HRAS, PTPRC, IL10, NCK1, PIK3R1,
IKBKB, AKT1, MAP3K14, IKBKG
hsa04625 C-type lectin receptor signaling 42 BCL3, MAPK1, NFKBIA, PIK3R2, NFKB1, IL2, MAPK14, IRF1, RAF1, KRAS,
pathway MDM2, MAPK3, IL1B, PIK3CA, PIK3CB, MALT1, NLRP3, PTPN11, CASP8,
STAT1, MAPKAPK2, PTGS2, NRAS, NFKB2, CHUK, BCL10, JUN, SYK, PIK3CD,
MAPK8, RELA, IL6, CYLD, MAPK9, TNF, HRAS, IL10, PIK3R1, IKBKB, AKT1,
MAP3K14, IKBKG
hsa04621 NOD-like receptor signaling 46 MAPK1, NFKBIA, MEFV, NAMPT, CCL2, NFKB1, MAPK14, TRAF2, RIPK1,
pathway MAPK3, IL1B, BIRC3, YWHAE, IFNAR1, IFNA1, IL18, BCL2L1, P2RX7,
HSP90AA1, NLRP3, TRPV2, JAK1, CASP8, STAT1, ATG5, CHUK, XIAP, JUN,
TLR4, TXN, IFNA2, IFNB1, MAPK8, BCL2, RELA, IL6, MAPK9, TNF, MYD88,
IKBKB, TRAF6, TRAF3, CCL5, BIRC2, TNFAIP3, IKBKG
hsa04623 Cytosolic DNA-sensing pathway 16 NFKBIA, NFKB1, RIPK1, IL1B, IFNA1, IL18, CXCL10, ADAR, CHUK, IFNA2,
IFNB1, RELA, IL6, IKBKB, CCL5, IKKG
hsa04672 Intestinal immune network for IgA 14 TGFB1, IL2, AICDA, IL4, CD80, IL15, CD28, CD86, CD40, CXCL12, IL6, CXCR4,
production IL6, MAP3K14

Volume 7 Issue 1 (2024) 8 https://doi.org/10.36922/itps.1076