Page 73 - ITPS-7-4

INNOSC Theranostics

and Pharmacological Sciences

ORIGINAL RESEARCH ARTICLE
Alleviation of oxidized lipid-induced oxidative

stress and hypertension by estrogen and
selected antihyperlipidemic drugs in

post-menopausal Wistar rats

4
Joy T. Folahan 1,2 , Adeoye O. Oyewopo , Olumuyiwa A. Adejumobi ,
3
1
6
1
Abayomi M. Ajayi , Saheed O. Afolabi , Olubunmi Atolani , Mary O. Ologe ,
5
1
4
Temidayo O. Omobowale , and Olufunke E. Olorundare *
1 Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, University of
Ilorin, Ilorin, Kwara State, Nigeria
2 School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of
Louisiana at Monroe, Monroe, Louisiana, United States of America
3 Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Kwara-State,
Nigeria
Abstract
Lipid peroxidation is implicated in the development of hypertension and coronary
artery disease, and its deleterious impact is exacerbated by estrogen (ETD)
*Corresponding author:
Olufunke E. Olorundare depletion in post-menopausal women. We hypothesize that treatment with ETD
(olufunke@unilorin.edu.ng) and antihyperlipidemic drugs, either alone or in combination, can alleviate the
Citation: Folahan JT, Oyewopo AO, development of cardiovascular disease. In this study, female Wistar rats were divided
Adejumobi OA, et al. Alleviation into 10 groups (n = 6): Group 1 (control) underwent a Sham operation and was fed
of oxidized lipid-induced standard rat chow, whereas the other nine groups were ovariectomized (OVX) and
oxidative stress and hypertension
by estrogen and selected received a diet containing either thermoxidized palm oil (TPO) or thermoxidized soya
antihyperlipidemic drugs in post- oil (TSO) for 12 weeks. ETD at 0.2 mg/kg/day, atorvastatin (ATV) at 10 mg/kg/day, and a
menopausal Wistar rats. INNOSC combination of ezetimibe (EZE) and ATV (EZE at 3 mg/kg/day + ATV at 10 mg/kg/day)
Theranostics and Pharmacological were administered for 12 weeks in both TSO and TPO diet groups. Blood pressure
Sciences. 2024;7(4):3901.
doi: 10.36922/itps.3901 and electrocardiogram (ECG) parameters were assessed, along with serum lipid
profile, atherogenic indices, and markers of oxidative stress. Both TPO and TSO diets
Received: June 10, 2024
significantly altered blood pressure and ECG parameters in OVX rats. Treatment with
Accepted: October 10, 2024 ATV, EZE+ATV, and ETD significantly reduced blood pressure parameters compared
Published Online: October 29, to the OVX+TPO group. Antihyperlipidemic drugs significantly decreased heart rate,
2024 QT interval, QRS duration, and QT corrected (QTc), whereas ETD similarly shortened
Copyright: © 2024 This the QRS and QTc duration. ATV and ETD also reduced total cholesterol, triglycerides,
is an Open-Access article and very low-density lipoprotein levels, while boosting high-density lipoprotein
distributed under the terms concentrations compared to untreated OVX+TSO rats. This study demonstrates that
of the Creative Commons
AttributionNoncommercial License, thermoxidized oil has a deleterious effect on OVX rats by altering blood pressure,
permitting all non-commercial use, ECG parameters, and atherogenic indices. Treatment with antihyperlipidemic drugs
distribution, and reproduction in any and ETD normalized blood pressure and ECG parameters, reversed hyperlipidemia,
medium, provided the original work
is properly cited. and restored antioxidant system balance.
Publisher’s Note: AccScience
Publishing remains neutral with Keywords: Thermoxidized oil; Lipid peroxidation; Oxidized low-density lipid; Menopause;
regard to jurisdictional claims in
published maps and institutional Cardiovascular diseases; Estrogen; Antihyperlipidemic drugs
affiliations.

Volume 7 Issue 4 (2024) 1 doi: 10.36922/itps.3901