Page 77 - ITPS-7-4

INNOSC Theranostics and
Pharmacological Sciences Estrogen treatment reverse hypertension

Table 3. Effects of estrogen and antihyperlipidemic drugs on serum lipid profiles in ovariectomized Wistar rats fed
thermoxidized soya oil
Treatment Serum lipid profile (mg/dL)
T‑CHOL TRIG HDL LDL VLDL
Sham 60.79±7.78 73.25±7.49 26.09±3.40 20.05±7.47 14.65±1.49
OVX 79.24±4.13 # 150.51±7.57 # 19.65±0.83 # 23.97±1.06 # 31.96±2.23 #
OVX+TSO 80.41±3.55 # 185.83±39.94 # 19.76±1.01 # 23.59±1.32 # 37.16±7.98 #
OVX+TSO+ATV 57.49±6.14*** 108.52±31.89*** 24.18±2.54*** 14.01±1.60*** 21.71±6.38***
OVX+TSO+EZE+ATV 69.58±6.08 148.54±45.85 28.03±1.04*** 11.84±0.87*** 29.71±9.17
OVX+TSO+ETD 74.29±6.24 113.81±23.79*** 33.18±1.51*** 18.36±0.95*** 22.76±4.76***
Notes: Values are expressed as mean±SEM. Statistical significance: #P<0.05 compared to Sham. *P<0.05 compared to OVX+TSO; **P<0.01 compared
to OVX+TSO; ***P<0.001 compared to OVX+TSO.
Abbreviations: ATV: Atorvastatin; ETD: Estradiol valerate; EZE: Ezetimibe; HDL: High-density lipoprotein; LDL: Low-density lipoprotein;
OVX: Ovariectomized; T-Chol: Total cholesterol; TRIG: Triglycerides; TSO: Thermoxidized soya oil; VLDL: Very low-density lipoprotein.

Table 4. Effects of estrogen and antihyperlipidemic drugs on serum lipid profiles in ovariectomized Wistar rats fed
thermoxidized palm oil
Treatment Serum lipid profile parameters (mg/dL)
T‑CHOL TRIG HDL LDL VLDL
Sham 60.79±7.78 73.25±7.49 26.09±3.40 20.05±7.47 14.65±1.49
OVX 79.24±4.13 # 150.51±7.57 # 19.65±0.83 # 23.97±1.06 # 31.96±2.23 #
OVX+TPO 80.27±4.21 # 192.40±9.05 # 19.69±1.96 # 22.10±1.20 38.48±1.81 #
OVX+TPO+ATV 77.09±1.91 121.09±15.12*** 24.45±2.18*** 27.75±1.37 24.22±3.02***
OVX+TPO+EZE+ATV 69.99±8.20 74.24±3.52*** 28.24±4.21*** 26.90±1.54 14.85±0.70***
OVX+TPO+ETD 61.61±2.26*** 103.77±11.39*** 24.84±2.01*** 16.02±1.02*** 20.75±2.28***
Notes: Values are expressed as mean±SEM. Statistical significance: P<0.05 compared to Sham; *P<0.05 compared to OVX+TPO; **P<0.01 compared to
#
OVX+TPO; ***P<0.001 compared to OVX+TPO.
Abbreviations: ATV: Atorvastatin; ETD: Estradiol valerate; EZE: Ezetimibe; HDL: High-density lipoprotein; LDL: Low-density lipoprotein;
OVX: Ovariectomized; T-Chol: Total cholesterol; TPO: Thermoxidized palm oil; TRIG: Triglycerides; VLDL: Very low-density lipoprotein.

Table 5. Effects of estrogen and antihyperlipidemic drugs on Table 6. Effects of estrogen and antihyperlipidemic drugs on
serum atherogenic indices in ovariectomized Wistar rats fed serum atherogenic indices in ovariectomized Wistar rats fed
thermoxidized soya oil thermoxidized palm oil
Treatment Atherogenic indices Treatment Atherogenic indices
AI CRI HDL/LDL AI CRI HDL/LDL
Sham 2.03±0.49 2.51±0.46 4.42±2.14 Sham 2.03±0.49 2.51±0.46 4.42±2.14
OVX 7.67±0.58 # 3.94±0.2 # 0.69±0.11 # OVX 7.67±0.58 # 3.94±0.2 # 0.69±0.11 #
OVX+TSO 8.87±2.38 # 4.19±0.29 # −0.12±1.01 # OVX+TPO 9.429±1.39 # 4.26±0.43 # 1.19±0.34 #
OVX+TSO+ATV 3.72±1.37*** 2.58±0.28*** 6.47±5.89*** OVX+TPO+ATV 4.22±0.89*** 3.27±0.27* 0.94±0.16
OVX+TSO+EZE+ATV 4.91±1.91*** 3.09±0.76** 0.44±0.71 OVX+TPO+EZE+ATV 1.99±0.57*** 2.91±0.76*** 3.03±1.67
OVX+TSO+ETD 2.62±0.65*** 2.63±0.57*** 0.30±2.24 OVX+TPO+ETD 3.41±0.69*** 2.55±0.21*** 1.78±0.35
Notes: Values are expressed as mean±SEM. Statistical significance: Notes: Values are expressed as mean±SEM. Statistical significance:
# P<0.05 compared to Sham; *P<0.05 compared to OVX+TSO; **P<0.01 # P<0.05 compared to Sham; *P<0.05 compared to OVX+TPO; **P<0.01
compared to OVX+TSO; ***P<0.001 compared to OVX+TSO. compared to OVX+TPO; ***P<0.001 compared to OVX+TPO.
Abbreviations: AI: Atherogenic index; ATV: Atorvastatin; Abbreviations: ATV: Atorvastatin; AI: Atherogenic index;
CRI: Coronary risk index; ETD: Estradiol valerate; EZE: Ezetimibe; CRI: Coronary risk index; ETD: Estradiol valerate; EZE: Ezetimibe;
HDL: High-density lipoprotein; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; LDL: Low-density lipoprotein;
OVX: Ovariectomized; TSO: Thermoxidized soya oil. OVX: Ovariectomized; TPO: Thermoxidized palm oil.

Volume 7 Issue 4 (2024) 5 doi: 10.36922/itps.3901