Page 76 - ITPS-7-4

INNOSC Theranostics and
Pharmacological Sciences Estrogen treatment reverse hypertension

A B

C D

Figure 1. Effects of estradiol and antihyperlipidemic drugs on electrocardiogram parameters in OVX Wistar rats fed thermoxidized soya and palm oil
diets. (A) Heart rate; (B) QRS interval; (C) QT interval; (D) QT corrected. Notes: Values are presented as mean±SEM. Statistical significance: P<0.05
#
compared to Sham; *P<0.05 compared to OVX+TSO/TPO; **P<0.01 compared to OVX+TSO/TPO; ***P<0.001 compared to OVX+TPO
Abbreviations: ATV: Atorvastatin; ETD: Estradiol valerate; EZE: Ezetimibe; OVX: Ovariectomized; TPO: Thermoxidized palm oil; TSO: Thermoxidized
soya oil.
Table 2. Effects of estradiol and antihyperlipidemic drugs on TPO groups compared to the Sham group. Treatment
blood pressure parameters in ovariectomized Wistar rats fed with ETD, ATV, and EZE + ATV reversed these effects,
thermoxidized palm oil significantly reducing QRS duration and QTc relative to
the diet-only TSO and TPO groups.
Treatment Blood pressure parameters (mmHg) a
SBP DBP MAP 3.3. ETD and antihyperlipidemic drugs improve lipid
Sham 107.30±3.87 78.25±3.10 87.46±2.09 metabolism in OVX rats treated with thermoxidized
OVX 109.20±3.02 83.87±2.15 90.06±1.48 oils
OVX+TPO 145.10±4.48 # 105.90±3.43 # 118.20±3.84 # Lipid metabolism was disrupted in OVX rats, as indicated
OVX+TPO+ATV 108.90±8.69** 76.58±4.75* 86.98±6.01* by significantly elevated total levels of cholesterol,
OVX+TPO+EZE+ATV 110.00±4.52* 76.70±3.59* 87.55±3.31* triglycerides, HDL-c, LDL-c, and VLDL compared to Sham
OVX+TPO+ETD 110.60±7.60* 77.54±8.01* 88.18±7.74* rats. OVX + TSO (Table 3) and OVX+TPO (Table 4) rats
Notes: Values are presented as mean±SEM. Statistical significance: exhibited similar effects, though more pronounced. CVD
a
#P<0.05 compared to Sham; *P<0.05 compared to OVX+TPO; **P<0.01. indices, such as AI and CRI, were elevated, whereas high-
Abbreviations: ATV: Atorvastatin; DBP: Diastolic blood pressure; density lipoprotein (HDL)/LDL ratios were significantly
ETD: Estradiol valerate; EZE: Ezetimibe; MAP: Mean arterial decreased (P < 0.05) in the OVX and diet-only groups
pressure; OVX: Ovariectomized; SBP: Systolic blood pressure; (Tables 5 and 6).
TPO: Thermoxidised palm oil.
Our results demonstrate that treatment with ETD
largely unchanged in the OVX group relative to the and antihyperlipidemic drugs restored normal lipid
Sham group. Conversely, QRS and QTc (P < 0.05) were metabolism in the treated rats, although each intervention
significantly prolonged in the OVX + TSO and OVX + exhibited a distinct mode of action. ETD increased HDL-c

Volume 7 Issue 4 (2024) 4 doi: 10.36922/itps.3901