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INNOSC Theranostics and
            Pharmacological Sciences                                           Image-assisted personalized interventions



            4.2. Prospective human in the loop and                position during the procedure. An intervention, such
            augmented DTs                                         as partial gastrectomy, whether performed using open,
            The abovementioned human-robot alliance (staff in the   laparoscopic, or robotic image-assisted techniques,
            loop) related to DT authorizes higher supervision of   involves the same surgical duration, with only the
            image-guided interventions, thus reducing the threat for   •   access being different.
                                                                  A complex procedure involves several compound-
            the patient and ensuring a guaranteed outcome for medical   interacting components characterized by  different
            staff. 83-85
                                                                  phenomena interacting in an interdependent manner,
              Furthermore, the  commitment of  the  practices  of   which is linked to the temporal and spatial behaviors
            artificial intelligence (AI) in such medical therapeutics   of the involved phenomena. The closer the time
            helps in reducing the complexity of data acquirement and   constants and the higher the matter local nonlinearities
            post-processing in MRI through strategy acceleration and   in phenomena, the stronger their interdependence
            providing quicker analysis periods with relaxed image   and, consequently, the greater the complexity. For
            processing. 86,87  AI can also be exploited to perform planned   distant time constants and linear matter behaviors,
            repeated training duties in image-assisted robotics related   this interdependence and related complexity are
            to the objective of the present paper.                greatly reduced. The concept of complexity is present
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              The procedure can be significantly enhanced through   in various natural and artificial occurrences  as well
            augmented human-robot  interactions, advancing  the   as societal issues.
            overall system with augmented reality (AR)-aided robotic   •   A complex procedure can be modeled mathematically
            actions. When combined with MRI, AR can reduce risks in   considering  its  compound-interacting  components
            complex procedures, such as tissue damage, bleeding, and   through the coupling of the equations governing the
            post-operative trauma. Moreover, DTs can play a significant   different phenomena interacting in an interdependent
            role in AR-supported robotic procedures. This allows for   manner. The more complex the procedure and its
                                                                  related phenomena interdependence, the more will
            precise identification of the source of the disorder and   be the complexity of the coupled model. For stronger
            the necessary action, using individual patient modeling   phenomena  interdependence (near  time  constants
            from deep learning databases. Furthermore, the AR–DT   and nonlinear matter behavior), the equations would
            combination enhances accuracy in suturing, knotting, and   be strongly coupled (solved simultaneously). In the
            placement compared to manual operations. 88-92
                                                                  case of low interdependence (distant time constants
            5. Discussion                                         and linear behavior), the equation coupling would be
                                                                  weak (iterative solution). Furthermore, the solution of
            In previous analyses, image-guided interventions have   the concerned equations should account for diverse
            been comprehensively discussed and illustrated. Different   topographies of modeled assemblies, which reflect
            necessary concepts or notions have been mentioned and   geometrical complexity, variables nonlinear behaviors,
            used in these developments, which include complete    and interdependence of phenomena. Satisfying such
            coupled and reduced models, complexity, and matched   characteristics inflicts a local solution in the matter
            real–virtual pairs. These aspects  are further developed   suggesting the practice of discretized 3D methods
            (extensions, reflections, or connected matters) and   as finite elements (FEM) or comparable methods.
            discussed in the following points:                    More details regarding the types of discretized
            •   Historically, the concerns related to the minimally   elements, domain meshing, methods mixing, and
               invasive surgical approach can be summarized as    numerical methodology are described elsewhere, 94-103
                                                  th
               follows. Since the beginning of the 19   century,   accompanying appropriate strategies for equations
               open surgery through laparotomy was practiced      coupling, with more details described elsewhere.
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               until the middle of the 20   century based on the   These  coupled  solutions  would  faithfully  represent
                                      th
               argument that “you could see better with open      the behavior of the complex procedure. However, they
               surgery.” Then, laparoscopic minimally invasive    reflect an important computation time and could not
               surgery revolutionized the approach to specific areas   be suitable for real-time executions.
               of  the  human  body  by providing an  enlarged  view   •   In the case of repetitive or online real-time
               through a tiny video camera and light at the end   computations,  complete  coupled  models  would  be
               of a thin tool. Robotic image-assisted surgery is a   penalizing, and hence reduced models should be used.
               successor to laparoscopic surgery, offering significant   Reducing a  model  involves  hastening  its  solution
               technological advancements and reducing staff fatigue   while debasing its accuracy as slight as possible;
               by allowing  them to maintain a more comfortable   more  details  are  described  elsewhere.   The  trouble
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            Volume 8 Issue 1 (2025)                         6                                doi: 10.36922/itps.4567
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