Page 43 - ITPS-8-2

INNOSC Theranostics and
Pharmacological Sciences MDD biomarkers: Clinical implications

Table 3. miR expression for MDD diagnosis
Tissue miR Expression Associated signaling pathways References
PBMCs (human) Upregulated GO, KEGG, and BioCarta 53
miR-26b, miR-4743, miR-4498, miR-4485 and miR-1972
PBMCs (human) Upregulated Wnt/VEGF/mTOR/ErbB pathways 51
miR-26b, miR-1972, miR-4485, miR-4498, and miR-4743
Downregulated
miR-338
CSF (human) Upregulated Serine protein kinases 54
miR-125a-5p, miR-30a-5p, let-7d-3p, miR-34a-5p, miR-221-3p, 5HT/CRH/Glu/Wnt/VEGF/mTOR/
miR-29b-3p, miR-10a-5p, miR-375, miR-155-5p, miR-33a-5p, ErbB/LTD pathways
miR-139-5p.
Downregulated
miR-185-5p, miR-590-5p
miR-106b-5p, miR-15Bb-5p, miR-451a
Serum (human) Upregulated
miR-221-3p, miR-34a-5p, let-7d-3p
Downregulated
miR-451
CSF and serum Downregulated Serotonin pathway 55
(human and rat) miR-16
PBMCs Upregulated Wnt/mTOR/ErbB/insulin/Jak-STAT 56
miR-199a-5p, miR-24-3p and miR-425-3p pathway
Downregulated
miR-1915-3p, let-7a-5p, let-7d-5p and let-7f-5p
Blood Upregulated BRPF1 (required for mouse 57
(human) pmiR-chr11, miR-3158-3p, miR-433, miR-3944-5p hippocampus development)
Downregulated
miR-1275, miR-4516, miR-30e-3p, miR-148b-3p
Hippocampus Downregulated NO and cytokines inflammatory 58
(mouse) miR-124 pathway
PBMCs, Downregulated TLR4 signaling pathway 59
monocytes PBMC: let-7e, miR-146a, and miR-155
(human) Monocytes: miR-146a and miR-155
(Both upregulated after treatment)
Plasma (human) Downregulated 60
miR-184
PBMCs (human) Upregulated CC chemokine receptor activity, T 47
ENSG00000238243.3_1, ENSG00000126353.3_2 cell receptor pathways.
ENSG00000198034.10_1, ENSG00000254996.5_2
ENSG00000184613.10_2, ENSG00000139193.3_2
ENSG00000101224.17_1, ENSG00000197153.4_2
ENSG00000103064.13_2, ENSG00000256235.1_1
Downregulated
ENSG00000150991.14_2, ENSG00000172057.9_2
Plasma (human) Upregulated Microglial activation pathway 61
Hippocampus, miR-134
PFC (rat)
Extracellular Downregulated Microglial activation pathway 62
vesicles miR-92a-3p
miR-129-5p
PFC miR-194-5p, miR-25-3p, miR-125-5p Th17 differentiation in the immune 63
system
Abbreviations: BRPF1: Bromodomain and PHD finger-containing protein 1; CSF: Cerebrospinal fluid; CRH: Corticotropin releasing
hormone; Glu: Glutamate; lncRNA: Long non-coding RNAs; LTD: Long-term depression; MDD: Major depressive disorder; miR: microRNA;
mTOR: Mammalian target of rapamycin; NO: Nitric oxide; PBMC: Peripheral blood mononuclear cells; PFC: Prefrontal cortex; VEGF: Vascular
endothelial growth factor; 5HT: 5 – hydroxyl tryptan.

Volume 8 Issue 2 (2025) 37 doi: 10.36922/itps.4404