Page 66 - JCTR-10-1

Journal of Clinical and Translational Research 2024; 10(1): 62-71

Journal of Clinical and Translational Research

Journal homepage: http://www.jctres.com/en/home

ORIGINAL ARTICLE

Prognostic factors and nomogram construction for primary retroperitoneal

myxoid/round cell liposarcoma: an analysis of population-based data

Aobo Zhuang 1,2† , Yingxue Cheng 1,2† , Zhe Xi 1,2† , Guangting Yan , Yue Wang , Geng Zhang , Jialiang Zheng ,
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Kun Chen , Qing Wang , Lanlan Lian , Xi Li , Tao Yu *, Fuan Xie *, Ting Wu *, Wengang Li 1,2,3 *
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1 Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China, Xiamen University Research Center of Retroperitoneal
Tumor Committee of Oncology Society of Chinese Medical Association, Xiamen University, Xiamen, Fujian 361102, P China, Department of
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Hepatobiliary Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China, Department of
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Laboratory Medicine, Xiang’an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian 361102, China, Department of Biostatistics, School
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of Public Health, Harvard University, Cambridge, MA 02138 , USA, College of Arts and Science, Boston University, Boston, MA, USA
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† These authors contributed equally to this work.
ARTICLE INFO ABSTRACT
Article history: Background: It has been reported that the prognosis for myxoid/round cell liposarcoma
Received: September 27, 2023 (MLPS/RCLPS) is inconsistent across different sites. However, there are neither prognostic studies
Accepted: December 13, 2023 nor predictive models that focused on MLPS/RCLPS of retroperitoneal origin.
Published online: February 5, 2024 Methods: Utilizing the Surveillance, Epidemiology, and End Results database, we selected
171 primary retroperitoneal MLPS/RCLPS cases from the period between 2000 and 2019. Prognostic
Keywords: factors influencing disease-specific survival were identified through Cox regression analysis. These
Retroperitoneal sarcoma independent prognostic factors were then used to construct a DSS nomogram prediction model. The
Myxoid/Round cell liposarcoma accuracy and reliability of this nomogram were evaluated using the concordance index (C-index)
Prognostic factors and calibration plots. Furthermore, we categorized patient prognosis using an X-tile based on the
Nomogram nomogram score.
Results: The observed 5-year and 10-year DSS rates for all patients were 64.0%
*Corresponding authors: (95% CI: 56.2% – 71.8%) and 47.1% (95% CI: 38.1% – 56.1%), respectively. The patient cohort
Wengang Li had a median age of 64 years, ranging from 24 to 92 years, with a slight male predominance (n = 92,
Cancer Research Center, School of Medicine, 53.8%) over females (n = 79, 46.2%). Distant metastases were diagnosed in 24 patients (14%). The
Xiamen University, Xiamen, Fujian 361102, China. distribution of MLPS and RCLPS was 89.5% and 10.5%, respectively. In terms of treatment, adjuvant
Email: lwgang@xmu.edu.cn radiotherapy was administered to 33 patients (19.3%), neoadjuvant radiotherapy to 9 patients (5.3%),
Ting Wu and chemotherapy to 20 patients (11.7%), while a significant majority (83.6%) underwent surgical
Cancer Research Center, School of Medicine, procedures. Independent prognostic factors for DSS included age (HR = 1.039, P < 0.001), marital
Xiamen University, Xiamen, Fujian 361102, China. status (P = 0.029), history of previous tumors (HR = 0.257, P = 0.007), presence of metastatic disease
Email: wuting78@189.cn (HR = 2.206, P = 0.027), and surgical treatment (HR = 0.490, P = 0.036). A nomogram prediction
Fuan Xie
Cancer Research Center, School of Medicine, model was constructed to forecast 1-, 5-, and 10-year DSS rates, with a C-index of 0.739. Calibration
Xiamen University, Xiamen, Fujian 361102, China. plots demonstrated a strong correlation between the nomogram’s predictions and actual observations.
Email: 406205761@qq.com Based on the prediction model, patients were stratified into three groups, and significant differences in
prognosis were observed between these groups.
© 2024 Author(s). This is an Open-Access Conclusion: A poorer prognosis is associated with retroperitoneal-derived MLPS/RCLPS than with
article distributed under the terms of the other sites. The nomogram prediction model we built can be used to assist patients in consulting with
Creative Commons Attribution-Noncommercial their doctors and selecting patients for clinical trials.
License, permitting all non-commercial use, Relevance for Patients: Our study highlights the unique challenges and prognosis variations in
distribution, and reproduction in any medium, retroperitoneal myxoid/RCLPS. The developed nomogram serves as a valuable tool for patients, aiding
provided the original work is properly cited.
informed discussions with doctors and guiding decisions on treatment and clinical trial participation.

DOI: https://doi.org/10.36922/jctr.00113