Page 49 - JCTR-9-4

Journal of Clinical and Translational Research 2023; 9(4): 265-271

Journal of Clinical and Translational Research

Journal homepage: http://www.jctres.com/en/home

ORIGINAL ARTICLE

Quality of life assessment in the first episode of acute coronary syndrome

Smitha Pernaje Seetharam , Vinutha Shankar *, Kaviraja Udupa , Raveesha Anjanappa , Niranjan Reddy 5
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1 Department of Physiology, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India, Department of Physiology,
Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India, Department of
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Neurophysiology, NIMHANS, Bengaluru, Karnataka, India, Department of General Medicine, R. L. Jalappa Hospital, Sri Devaraj Urs Academy of
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Higher Education and Research Kolar, Karnataka, India, Department of Cardiology, R. L. Jalappa Hospital, Sri Devaraj Urs Academy of Higher
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Education and Research, Kolar, Karnataka, India
ARTICLE INFO Abstract
Article history: Background: Assessment of health-related quality of life (HRQoL) is an important measure of a
Received: March 10, 2023 patient’s recovery after an illness. However, HRQoL among acute coronary syndrome (ACS) survivors
Revised: April 19, 2023 has not been extensively studied following cardiac management.
Accepted: June 26, 2023 Aim: The purpose of this study was to assess the quality of life (QoL) among ACS patients who have
Published: July 26, 2023 undergone percutaneous coronary intervention (PCI).
Methods: This cohort study included 145 consecutive male ACS patients between March 2021 and
Keywords: May 2022. Of these patients, 138 (mean age 54.3 ± 10.7 years) completed the QoL assessment using
Myocardial infarction the short form-12 (SF-12) health survey questionnaire. Seventy (51%) of them presented with ST-
Sudden death segment elevation myocardial infarction (STEMI), 18 (13%) had non-STEMI, 39 (28%) had evolved
Quality of life MI, and 11 (8%) had unstable angina. Recruited patients’ QoL data were assessed at various time
Acute coronary syndrome points post-PCI.
Health survey Results: At the end of the 12 months of follow-up, major clinical events (MCE) defined as death,
sudden death, or re-acute myocardial infarction occurred in 54.9% of patients. Out of 7 MCE, four
*Corresponding authors: deaths and three re-AMIs had occurred. SF-12 physical component score was found to be significantly
Vinutha Shankar improved when compared to the mental component score, which seems to improve without reaching
Department of Physiology, Sri Devaraj Urs statistical significance over time. Among event-free ACS patients, we found a significant positive
Medical College, Sri Devaraj Urs Academy correlation between left ventricular ejection fraction and HRQoL.
of Higher Education and Research, Tamaka, Conclusion: Improvement in HRQoL (physical component) was seen among ACS patients post-PCI.
Kolar - 563 103, Karnataka, India. Relevance for Patients: QoL assessment outcomes should be considered in clinical settings, practice
Tel: +91-9845065374/+91-08152 243003. guidelines, and treatment modality post-PCI to improve QoL in post-ACS survivors.
Fax: +91 (8152) 243008.
Email: vinutha.shankar@gmail.com

© 2023 Author(s). This is an Open-Access
article distributed under the terms of the 1. Introduction
Creative Commons Attribution-Noncommercial
License, permitting all non-commercial use, Acute coronary syndrome (ACS) is a term used to describe one of two conditions:
distribution, and reproduction in any medium, A heart attack (myocardial infarction) or when a person suffering from severe chest pain
provided the original work is properly cited. (unstable angina). Myocardial infarction is further classified as ST-segment elevation
myocardial infarction (STEMI) and non-STEMI (NSTEMI). India has the world’s highest
ACS burden as shown by a prospective registry study (CREATE) which generated data
from ten regions and 50 cities in 89 centers [1]. Even though the advent of therapies has
increased survival in ACS, the rates of event-free survival at 1 year and 2 years were 88
± 60.3% for males and 83% for females, respectively (P = 0.58) [2]. In addition, persons
who have ACS report significant physical and mental discomfort related to the condition
and subsequent clinical management. Hence, there is a need to understand the effects of

DOI: http://dx.doi.org/10.18053/jctres.09.202304.23-00049