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270 Seetharam et al. | Journal of Clinical and Translational Research 2023; 9(4):265-271
one of the prognostic evaluators for QoL among ACS survivors. and Interventions. Effect of Percutaneous Coronary
Further, we analyzed the overall effect of various confounding Intervention on Quality of Life: A Consensus Statement
factors on QoL post-PCI in patients with and without MCE. Since from the Society for Cardiovascular Angiography and
no significant association between confounding factors and QoL Interventions. Catheter Cardiovasc Interv 2013;81:243-59.
was observed, future studies could analyze the effect of risk factors [5] Ware JE Jr., Sherbourne CD. The MOS 36-Item Short-form
(especially comorbidities such as HTN and diabetes mellitus) on Health Survey (SF-36). I. Conceptual Framework and Item
QoL among patients who had MCE. The study population was Selection. Med Care 1992;30:473-83.
heterogeneous in terms of clinical presentation, comorbidities, [6] Failde I, Medina P, Ramírez C, Arana R. Assessing Health-
and pathophysiology. In accordance, QoL and ejection fraction Related Quality of Life among Coronary Patients: SF-36
would be different between patients with STEMI and unstable vs SF-12. Public Health 2009;123:615-7.
angina patients. Besides, if an unstable angina patient undergoes [7] Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB,
PCI for the culprit lesion, the patient would be relieved of any Brazier JE, et al. Cross-Validation of Item Selection and
symptoms, and hence, their ejection fraction would be normal. Scoring for the SF-12 Health Survey in Nine Countries:
Hence, future studies should focus further research on QoL post- Results from the IQOLA Project. J Clin Epidemiol
acute MI/STEMI patients only.
1998;51:1171-8.
5. Conclusions [8] Abrootan S, Yazdankhah S, Payami B, Alasti M. Changes
in Heart Rate Variability Parameters After Elective
The present study results revealed a significant increase in Percutaneous Coronary Intervention. J The Univ Heart Ctr
the physical component of QoL from 1 to 6 months post-PCI 2015;10:80-4.
among ACS survivors. QoL scores correlated well with the
echocardiographic measure of LV ejection fraction. Further, [9] Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL,
age had a significant negative effect on QoL. Therefore, QoL Birtcher KK, et al. 2021 AHA/ACC/ASE/CHEST/
assessment outcomes should be considered in routine clinical SAEM/SCCT/SCMR Guideline for the Evaluation and
practice and treatment modality post-PCI to improve QoL. Diagnosis of Chest Pain: A Report of the American
College of Cardiology/American Heart Association Joint
Acknowledgments Committee on Clinical Practice Guidelines. Circulation
2021;144:e368-454.
The authors appreciate the assistance of all the investigators
who worked on this study and all the volunteers who offered their [10] Collet JP, Thiele H, Barbato E, Barthe´le´my O,
Bauersachs J, Bhatt DL, et al. 2020 ESC Guidelines for
time to take part.
the Management of Acute Coronary Syndromes in Patients
Funding Presenting without Persistent ST-Segment Elevation.
The Task Force for the Management of Acute Coronary
None. Syndromes in Patients Presenting without Persistent ST-

Conflicts of Interest Segment Elevation of the European Society of Cardiology
(ESC). Eur Heart J 2021;42:1289-367.
The authors claim to have no conflicts of interest. [11] U.S. Department of Health and Human Services. The

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