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266 Seetharam et al. | Journal of Clinical and Translational Research 2023; 9(4):265-271
ACS impact on the physical and mental health status of ACS Further, not many studies have looked into the effect of
survivors. comorbidities on the quality of life (QoL) measured post-PCI.
A self-administered generic tool short-form health survey Therefore, this study aimed to evaluate the QoL among ACS
(SF-36) has been used in angina, acute myocardial infarction patients post-PCI using the SF-12 health survey questionnaire and
(AMI), and heart failure. The SF-36 has been demonstrated to to explore the effect of comorbidities on QoL.
be a sensitive measure for identifying improvements in HRQoL
following active intervention in individuals with recent AMI. 2. Materials and Methods
The SF-12 and SF-8 are condensed forms of the questionnaire
which are accessible for use and are quicker to complete [3]. 2.1. Study setting
Multiple studies have shown that QoL is better after PCI than This cohort study was conducted at the Cardiology outpatient
it was before. Complete angina resolution was better with PCI, department, R.L. Jalappa Hospital, in association with the
according to a meta-analysis of 14 randomized controlled trials Department of Physiology, attached to Sri Devaraj Urs Medical
comparing PCI to medical therapy in 7818 patients enrolled College, Kolar, Karnataka, India.
from 1987 to 2005. Furthermore, it has been observed that the
SF-12, or condensed version of the SF-36, correlates favorably 2.2. Ethical consideration
with the SF-36 summary scores in a variety of illnesses,
including angina [4]. Central Ethics Committee clearance was obtained (CEC No.
The reason for using the SF-12 health survey questionnaire was SDUAHER/KLR/R & I/91/2021-22). Each participant provided
with only 12 items, health status could be assessed aptly when written informed consent to participate in the study.
compared to the 36-item SF-36 [5]. The SF-12 questionnaire has The sample size was calculated [8] using nMaster 2.0 software
been proven to be accurate in a variety of medical conditions as and was estimated with 0.9 as the statistical power and <0.05 as
well as in the general population [6,7]. the significant P-value (Figure 1).

Figure 1. Study flow before and after PCI.
Abbreviations: PCI: Percutaneous coronary intervention; BA: Bronchial asthma; S/P PCI: Status post-PCI; MI: Myocardial infarction; UA: Unstable
angina; POBA: Percutaneous old balloon angioplasty; RA: Rheumatoid arthritis; CABG: Coronary artery bypass graft; IHD: Ischemic heart disease;
STEMI: ST elevation myocardial infarction; NSTEMI: Non-ST elevation MI; STK: Streptokinase; RTP: Reteplase; TNK: Tenecteplase; CAG:
Coronary angiogram; MACE: Major adverse cardiac event; PCS: Physical component score; MCS: Mental component score; QoL: Quality of life;
LVEF: Left ventricular ejection fraction.
DOI: http://dx.doi.org/10.18053/jctres.09.202304.23-00049