Page 56 - JCTR-9-6

420 Mustahsan et al. | Journal of Clinical and Translational Research 2023; 9(6): 414-422
and biologically. Many iterations need to be done on the design Analysis. J Bone Joint Surg Am 2007;89:649-58.
side to achieve the balance between having the ideal porosity to [7] Finkemeier CG. Bone-grafting and Bone-graft Substitutes.
facilitate the bone growth and providing the structural strength to J Bone Joint Surg Am 2002;84:454-64.
the affected bone. [8] Tomford WW. Transmission of Disease through
5. Conclusions Transplantation of Musculoskeletal Allografts. J Bone
Joint Surg Am 1995;77:1742-54.
We successfully demonstrated that our MED610 3D-printed [9] Buck BE, Malinin TI, Brown MD. Bone Transplantation
scaffolds are suitable for implantation as they are biocompatible and Human Immunodeficiency Virus. An Estimate of Risk
and do not cause any adverse reaction when implanted. We also of Acquired Immunodeficiency Syndrome (AIDS). Clin
found that the CRFP-coated MED610 scaffolds generate more Orthop Relat Res 1989;240:129-36.
ectopic bone growth when implanted and contribute to bio- [10] Boyce T, Edwards J, Scarborough N. Allograft Bone.
integration. The Influence of Processing on Safety and Performance.
Acknowledgments Orthop Clin North Am 1999;30:571-81.
[11] Mroz TE, Joyce MJ, Steinmetz MP, Lieberman IH,
The authors gratefully acknowledge the support provided by the Wang JC. Musculoskeletal Allograft Risks and Recalls
Department of Anesthesiology, Renaissance School of Medicine, in the United States. J Am Acad Orthop Surg 2008;16:
Stony Brook, NY. 559-65.
Conflicts of Interst [12] Ullmark G, Obrant KJ. Histology of Impacted Bone-graft
Incorporation. J Arthroplasty 2002;17:150-7.
The authors declare that there are no conflicts of interest. [13] Fernandez de Grado G, Keller L, Idoux-Gillet Y,

Ethics Approval and Consent to Participate Wagner Q, Musset AM, Benkirane-Jessel N, et al. Bone
Substitutes: A review of their Characteristics, Clinical Use,
No human subjects were involved in this study. All procedures and Perspectives for Large Bone Defects Management.
involving animals were reviewed and approved by the Institutional J Tissue Eng 2018;9:2 041731418776819.
Animal Care and Use Committee of Stony Brook University [14] Wang JC, Alanay A, Mark D, Kanim LE, Campbell PA,
(IACUC protocol number: 1503487). Dawson EG, et al. A Comparison of Commercially
Consent for Publication Available Demineralized Bone Matrix for Spinal Fusion.
Eur Spine J 2007;16:1233-40.
Not applicable. [15] Gruskin E, Doll BA, Futrell FW, Schmitz JP, Hollinger JO.
References Demineralized Bone Matrix in Bone Repair: History and
Use. Adv Drug Deliv Rev 2012;64:1063-77.
[1] Sohn HS, Oh JK. Review of Bone Graft and Bone [16] Campana V, Milano G, Pagano E, Barba M, Cicione C,
Substitutes with an Emphasis on Fracture Surgeries. Salonna G, et al. Bone Substitutes in Orthopaedic Surgery:
Biomater Res 2019;23:9. From Basic Science to Clinical Practice. J Mater Sci Mater
[2] Myers GJ, Abudu AT, Carter SR, Tillman RM, Grimer RJ. Med 2014;25:2445-61.
Endoprosthetic Replacement of the Distal Femur for [17] Russell N, Walsh WR, Lovric V, Kim P, Chen JH,
Bone Tumours: Long-term Results. J Bone Joint Surg Br Larson MJ, et al. In-vivo Performance of Seven
2007;89:521-6. Commercially Available Demineralized Bone Matrix Fiber
[3] Plotz W, Rechl H, Burgkart R, Messmer C, Schelter R, and Putty Products in a Rat Posterolateral Fusion Model.
Hipp E, et al. Limb Salvage with Tumor Endoprostheses Front Surg 2020;7:10.
for Malignant Tumors of the Knee. Clin Orthop Relat Res [18] Chung HJ, Hur JW, Ryu KS, Kim JS, Seong JH. Surgical
2002;405:207-15. Outcomes of Anterior Cervical Fusion Using Deminaralized
[4] Engh CA, Bobyn JD, Glassman AH. Porous-coated Hip Bone Matrix as Stand-Alone Graft Material: Single Arm,
Replacement. The Factors Governing Bone Ingrowth, Pilot Study. Korean J Spine 2016;13:114-9.
Stress Shielding, and Clinical Results. J Bone Joint Surg [19] Saikia KC, Bhattacharya TD, Bhuyan SK, Talukdar DJ,
Br 1987;69:45-55. Saikia SP, Jitesh P. Calcium Phosphate Ceramics as Bone
[5] Epari DR, Taylor WR, Heller MO, Duda GN. Mechanical Graft Substitutes in Filling Bone Tumor Defects. Indian J
Conditions in the Initial Phase of Bone Healing. Clin Orthop 2008;42:169-72.
Biomech (Bristol, Avon) 2006;21:646-55. [20] Hing KA, Wilson LF, Buckland T. Comparative
[6] De Long WG Jr., Einhorn TA, Koval K, McKee M, Performance of Three Ceramic Bone Graft Substitutes.
Smith W, Sanders R, et al. Bone Grafts and Bone Graft Spine J 2007;7:475-90.
Substitutes in Orthopaedic Trauma Surgery. A Critical [21] Flatley TJ, Lynch KL, Benson M. Tissue Response to
DOI: http://dx.doi.org/10.18053/jctres.09.202306.23-00097