Page 64 - MSAM-1-4

Materials Science in Additive Manufacturing LPBF of Mg and its bio-applications

Usually, the regeneration cycle of bone tissue is very long, 52165043, 82072084); (2) JiangXi Provincial Natural
and the implant needs to remain in the body for about 6 – Science Foundation of China (20212BAB214026); and
12 months to fully the reconstruct bone tissue. Bone healing (3) Jiangsu Provincial Key Research and Development
goes through three necessary stages: Inflammation, repair, Program (BE2019002).
and bone remodeling. In the first two stages, the bone defect
site cannot bear weight, and implants are needed to provide Conflict of interest
sufficient support to prevent secondary injury. Therefore, in The authors declare that they have no competing financial
the early stage of healing, Mg alloy implants are required to interests that could have influenced the work reported in
have high mechanical strength to provide sufficient support; this paper.
at the same time, a low degradation rate must be maintained
to maintain the integrity of the mechanical structure and Author contributions
prevent mechanical failure due to excessive degradation. In Conceptualization: Chuyi Liu, Chengrong Ling, and
addition, it can avoid problems such as swelling and local Dongsheng Wang
alkalinity caused by the production of a large amount of Funding acquisition: Youwen Yang
H , which results in inflammation of the implantation site. Supervision: Youwen Yang and Cijun Shuai
2
Therefore, improving the corrosion resistance of Mg alloys Writing – original draft: Chuyi Liu
has become a top priority.
Writing – review & editing: Chengrong Ling, Cheng Chen,
5. Conclusions Youwen Yang, Deqiao Xie, and Cijun Shuai

This paper reviews the research progress in the field of laser All authors have read and agreed to the published
AM of Mg alloys, and summarizes and compares their powder version of the manuscript.
preparation, process parameters, and post-processing. References
Biological Mg alloys show great application potential in the field
of tissue engineering due to their good mechanical properties, 1. Xing F, Li S, Yin D, et al., 2022, Recent progress in Mg-based
natural degradability, and biocompatibility. However, under alloys as a novel bioabsorbable biomaterials for orthopedic
the complex human physiological environment, the corrosion applications. J Magnes Alloys, 10: 1428–1456.
rate cannot be effectively controlled. The follow-up research https://doi.org/10.1016/j.jma.2022.02.013
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(i) Further studying the influence of alloying nanohydroxyapatite zoledronate scaffold seeded with bone
elements on the mechanical properties of Mg alloys, marrow mesenchymal stromal cells for bone regeneration:
analyzing the changing trend of the mechanical properties A 3d in vitro model. Int J Mol Sci, 23: 5988.
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and blood to find out the influencing factors, corrosion https://doi.org/10.1016/j.ijbiomac.2022.06.137
mechanism and corrosion laws in the corrosion process, 4. Ni J, Ling H, Zhang S, et al., 2019, Three-dimensional
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(iii) Setting up dynamic simulation environment, https://doi.org/10.1016/j.mtbio.2019.100024
simulating the degradation behavior of Mg alloys in vivo, 5. Li J, Qin L, Yang K, et al., 2020, Materials evolution of bone
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Acknowledgments J Mater Sci Technol, 36: 190–208.
https://doi.org/10.1016/j.jmst.2019.07.024
The authors would also like to thank the Institute of AM of
Jiangxi University of Science and Technology. 6. Zhang B, Su Y, Zhou J, et al., 2021, Toward a better regeneration
through implant-mediated immunomodulation: Harnessing
Funding the immune responses. Adv Sci, 8: 2100446.

This study was supported by the following funds: (1) https://doi.org/10.1002/advs.202100446
National Natural Science Foundation of China (51935014, 7. Bairagi D, Mandal S 2022, A comprehensive review on

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