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Materials Science in Additive Manufacturing                      MAM for orthopedic bone plates: An overview



            to markedly bolster the microstructural and mechanical   integrity, which can be tailored through post-processing,
            attributes of Ti6Al4V alloy samples.               determines how a bone plate will interact with the
              Hybrid  manufacturing  presents  a  constellation  of   biological environment. An optimized surface can reduce
            advantages, including elevated efficiency, improved product   corrosion, minimize bacterial adhesion, and promote
            quality, and a marked reduction in material wastage . Yet,   osseointegration, ensuring the long-term success of the
                                                     [90]
                                                                     [91]
            as a nascent technology, it grapples with hurdles. Limited   implant . On the other hand, a compromised surface can
                                                                                                        [92]
            accessibility to specialized machines, intricate integration   have severe repercussions, including implant failure .
            demands, and an augmented necessity for rigorous quality   Research findings emphasize the nuanced role of post-
            assurance stand out as prominent challenges.       processing. Jahadakbar et al.’s work  on porous nitinol
                                                                                            [43]
              In the domain of bone plate manufacturing, the   bone fixation plates illustrates the efficacy of chemical
            evolution from traditional subtractive methods to   polishing in removing unmelted powder residues while
            revolutionary AM techniques, and ultimately to hybrid   preserving intricate geometries. The scanning electron
            approaches, showcases the industry’s relentless pursuit of   microscopy analysis of their study specifically found that
            innovation. Subtractive manufacturing, while proficient in   an etching solution composed of 10% HF, 40% HNO , and
                                                                                                         3
            mass production, often encounters limitations in crafting   50% H O, applied for an effective time of 4 min, was optimal
                                                                    2
            patient-specific solutions. AM techniques, especially   for removing unmelted powder particles. Such meticulous
            PBF,  introduce  unparalleled  flexibility  in  crafting   post-processing is essential, especially when catering to
            intricate, customized designs, although with its own set   patient-specific needs that require high precision.
            of  challenges,  such  as  high  costs  and  post-processing   Heat treatment plays a pivotal role in refining the
            demands. The most recent stride in this journey is the   mechanical attributes of  AM components.  Research  by
            advent of hybrid manufacturing, which marries the   Gupta  et al.  showcased the potential of this method,
                                                                         [93]
            strengths of both subtractive and additive processes. This   focusing on Ti-6Al-4V plates produced through SLM.
            synergistic approach aims to produce bone plates that boast   When  juxtaposed with  plates  machined  from  wrought
            the structural complexity enabled by AM, while retaining   sheets, the value-add of AM in orthopedics becomes
            the superior surface finish typical of subtractive methods.   evident. Nonetheless, while the immediate benefits
            However, the nascent state of hybrid manufacturing means   are clear, queries regarding the long-term stability and
            that its full potential is yet to be realized, necessitating   dependability of such treatments persist. These concerns
            further research and optimization, particularly given   become especially pertinent when AM techniques are
            the critical nature of bone plate applications where   compared with traditional manufacturing methods.
            structural integrity and biocompatibility are of paramount   Furthermore, heat treatment can significantly enhance
            importance.
                                                               material properties,  making  them  more suitable  for
                                                                                                           [71]
            4.4. Perfecting additive manufactured bone plates   biomedical applications. As elucidated by Hou  et al. ,
            with post-processing                               materials like the ZX11 magnesium alloy, although
                                                               promising, are subjected to rapid degradation. This raises
            AM has substantially expanded the horizons of medical   concerns about the longevity and stability of such implants.
            device production. However, the creation of a bone plate   Their study compared the degradation rates of the alloy in
            does not end with the completion of the printing process.   two states: as-rolled and annealed at 400°C. Their findings
            Post-processing – the series of operations performed after   revealed that while the annealed alloy exhibited relatively
            the initial AM process – plays a pivotal role in ensuring   lower strength, it benefited from a significantly reduced
            that the bone plates are not only structurally sound but   degradation rate and demonstrated stable elongation in the
            also biocompatible.                                initial weeks of immersion, underscoring the importance
              As the initial phase of AM often leaves parts with surface   of heat treatment in optimizing material performance for
            roughness or residual stresses, post-processing techniques   biomedical implants.
            such as heat treatment and surface modification become   Another significant facet of post-processing is surface
            indispensable. These treatments can profoundly impact   modification,  which  has  been  thoroughly  studied
            the mechanical properties of the printed parts, enhancing   concerning its impact on biocompatibility and cellular
            their strength and fatigue resistance, which are paramount   interactions. Surface characteristics, from roughness to
            for bone plates subjected to significant mechanical loads   chemical composition, can profoundly influence cell
            during their life cycle .                          adhesion, proliferation, and differentiation, as highlighted
                             [86]
              Equally significant is the impact of these treatments   by Gittens  et al.  and Stepanovska  et al. . While
                                                                                                     [87]
                                                                              [94]
            on the biomedical properties of the bone plates. Surface   these  alterations can  bolster implant performance,  they
            Volume 2 Issue 4 (2023)                         9                       https://doi.org/10.36922/msam.2113
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