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Materials Science in Additive Manufacturing Preparation and modification of porous Ti

A

B

Figure 12. Coatings prepared using different electrochemical methods. (A) Schematic diagram of anodizing processing and its working principle.
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Copyright © 2021 Elsevier. Reprinted with permission from Elsevier. (B) Micro-arc oxidation surface preparation principle and surface image. Copyright
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© 2023 Elsevier. Reprinted with permission from Elsevier.
4.3. Loaded drug or active substance unique three-dimensional network, good biocompatibility,
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The antibacterial and osteogenic effects of porous implants and cell adhesion. 117,118 Bai et al. constructed a porous
can be achieved by modifying the materials’ surface titanium/Poloxam 407 hydrogel system loaded with
morphology and chemical composition. However, it is zoledronate (ZOL) to promote bone integration in rabbit
often difficult to control the release time and content from osteoporosis models to inhibit local excessive bone absorption
the porous implants generated by methods such as metal and promote bone integration. The composite scaffold
element coating, a predicament that would cause certain (ZOL/gTi) showed good biocompatibility and continued to
damage to the human body. Thus, loading drugs, stem release ZOL as the hydrogel degraded (Figure 13A).
cells, or exoactive substances on the surface of porous Cell tissue modification refers to the culture of stem
scaffolds can greatly improve its safety. cells or their secretions in vitro and subsequently the
Due to the strict storage conditions required for modification of the surface of materials by gel loading or by
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drugs and bioactive substances, a much stringent set of culture with materials. Yu et al. encapsulated bone BMSCs
requirements should be applied in the design of carriers. into a matrix gel, as shown in Figure 13B. Subsequently, the
Hydrogels emerge as the ideal carriers of drugs and BMSC-containing matrix was infiltrated into the porous
bioactive substances due to their high hydrophilicity, Ti6Al4V scaffold surface to improve the extracellular

Volume 3 Issue 1 (2024) 16 https://doi.org/10.36922/msam.2753