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Materials Science in Additive Manufacturing Preparation and modification of porous Ti

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Figure 13. Porous titanium alloy bioactive coating for medical applications. (A) Preparation and effect of a gel-supported drug promoting bone formation.
(B) Hydrogel-supported BMSCs promoting bone repair coating Copyright © 2019 Hindawi. Reprinted with permission from Hindawi.
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environment of porous titanium alloys. Compared with the 4.4. Compound method
local injection of BMSCs, the modified Ti6Al4V scaffold Oftentimes, approaches such as surface modification of
promoted the formation of new bone at the mandibular porous implants, chemical composition adjustment, and active
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defect site in rats. Qiao et al. constructed pure titanium
scaffolds coated with platelet-rich plasma (PRP) by freeze- material loading would only produce implants with limited
drying. In vitro biological experiments showed that PRP- conducive functions or properties. In the context of addressing
coated porous titanium scaffolds significantly promoted the urgent needs to promote osteogenic and antibacterial
the attachment, proliferation, migration, and osteogenic effects, especially during the early stages of implantation, there
differentiation of bone marrow mesenchymal stem cells is increasing interest in unifying morphology modification
(BMSCs). In vivo studies of implant coatings using an and composition loading approaches to create multifunctional
osteoporosis model have shown that the bioactive interface implants. Therefore, combining morphology modification
of PRP coatings enhanced bone vitality. and composition loading to obtain multiple effects has become
one of the hot research topics.
Compared with changing the surface morphology of
materials and adding metal elements, loaded drugs or active Ag particles have antibacterial effects. Depending on
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substances have no side effects on damaged tissues, and this property, Croes et al. added different concentrations
their effectiveness and safety are significantly improved. of Ag nanoparticles to the chitosan-based (Ch) coating.
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However, this modification method necessitates excellent The Ch+Ag particle composite coating is endowed with
extraction and storage of surface materials. Hence, enhanced antibacterial properties than simple chitosan
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developing low-cost modification methods for active coating. Wei et al. prepared carbon nanotubes by
substances is one of the critical problems to be solved. electrophoretic deposition on the surface of porous titanium

Volume 3 Issue 1 (2024) 17 https://doi.org/10.36922/msam.2753