Page 58 - OR-1-2

A

B

C

Figure 6. The application of vascularized brain organoids for the study of neovascularization. (A) Recapture of cell subtypes in neurogenesis and
vascularization. Copyright © 2020, Authors. (B) The relationship between neurogenesis and vascularization in brain organoid. Copyright © 2022,
22
83
Authors. (C) The reconstruction of neurovascular blood-brain barrier. 174,176 Copyrights © 2020 and 2021, Authors.
Abbreviations: AIF1: Allograft inflammatory factor 1; Ast: Astrocyte; AQP4: Aquaporin-4; BOr: Brain organoid; Ch: Choroid plexus; CLDN5: Claudin
5; DAPI: 4’,6-diamidino-2-phenylindole; DCX: Doublecortin; Endo: Endothelial cell; EOMES: Eomesodermin; ExN: Excitatory neuron; fVBOr: Fused
vasculature and brain organoids; GAD1: Glutamate decarboxylase 1; GFAP: Glial fibrillary acidic protein; GFP: Green fluorescent protein;
HOPX: Homeodomain only protein X; Iba-1: Ionized calcium-binding adapter molecule-1; Im N: Immature neuron; IN: Interneuron; iNOS: Inducible
nitric oxide synthase; IPC: Intermediate progenitor cell; MGE: Medial ganglionic eminence; MGE div: MGE dividing cell; Mic: Microglia; MKI67:
Marker of proliferation Kiel 67; NEUROD2: Neuronal differentiation 2; NG2: Neuron-glial antigen-2; OLIG1: OPC: Oligodendrocyte progenitor cell;
oRG: Outer radial glia; PAX6: Paired box protein 6; p-VIM: Phospho-vimentin; RG: Radial glia; SOX2: SRY box transcription factor 2; VE: Vascular
endothelium; vOrganoid: Vascularized brain organoids.

Volume 1 Issue 2 (2025) 9 doi: 10.36922/or.8162