Page 107 - TD-3-4

Tumor Discovery Bioinformatics insights into CCL2 mutations

Specificity 0.57 0.18 0.91 0.56 0.58 0.69 0.68 0.98 0.46 0.54 0.54 0.83 0.84 0.98 0.9 0.66 0.85 0.69 0.93 0.93 1 0.81 0.59 0.85 0.73 0.93 0.45 0.79 0.84 0.74 (Cont’d...)

Sensitivity 0.95 0.99 0.66 0.95 0.94 0.91 0.91 0.27 0.97 0.95 0.95 0.81 0.79 0.18 0.69 0.92 0.78 0.91 0.62 0.59 0 0.83 0.94 0.78 0.89 0.61 0.97 0.84 0.79 0.88

PolyPhen-2 Score 0.023 0.002 0.936 0.02 0.026 0.103 0.1 0.997 0.007 0.015 0.015 0.587 0.651 0.998 0.906 0.075 0.718 0.107 0.965 0.976 1 0.487 0.029 0.712 0.178 0.967 0.006 0.41 0.653 0.208

Analysis Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging Possibly damaging

Benign Benign Benign Benign Benign Benign Benign Benign Benign Benign Benign Benign Benign Benign Benign Benign

Meta-SNP Score Analysis 0.248 Normal 0.084 Normal 0.669 Disease 0.49 Normal 0.069 Normal 0.116 Normal 0.241 Normal 0.582 Disease 0.076 Normal 0.08 Normal 0.085 Normal 0.328 Normal 0.325 Normal 0.733 Disease 0.661 Disease 0.089 Normal 0.6 Disease 0.236 Normal 0.612 Disease 0.637 Disease 0.916 Disease 0.296 Normal 0.086 Normal 0.26 Normal 0.111 Normal 0.56 Disease 0.12 Normal 0.175 Normal 0.21 No

Prediction of deleterious mutation SNAP Score Analysis 0.415 Normal 0.65 0.405 Normal 0.77 0.665 Disease 0.12 0.53 Disease 0.02 0.41 Normal 0.25 0.475 Normal 0.53 0.43 Normal 0.36 0.68 Disease 0.02 0.41 Normal 0.96 0.41 Normal 0.4 0.345 Normal 0.53 0.635 Disease 0.23 0.58 Disease 0.16 0.86 Disease 0.01 0.685 Disease 0.21 0.51 Disease 0.28 0.585 Disease 0.53 0.62 Disease 0.26 0.685 Disease 0.31 0

Analysis SIFT Score Normal Normal Normal Disease Normal Normal Normal Disease Normal Normal Normal Normal Normal Disease Normal Normal Normal Normal Normal Disease Disease Normal Normal Normal Normal Disease Normal Disease Disease Normal

PhD-SNP Score 0.245 0.072 0.634 0.482 0.054 0.116 0.223 0.416 0.08 0.084 0.074 0.404 0.311 0.647 0.539 0.085 0.455 0.216 0.485 0.518 0.857 0.223 0.043 0.211 0.105 0.626 0.124 0.128 0.159 0.454

Analysis Normal Normal Disease Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Disease Disease Normal Normal Normal Normal Disease Disease Normal Normal Normal Normal Disease Normal Normal Normal Normal

Score 0.128 0.182 0.703 0.468 0.11 0.161 0.173 0.653 0.207 0.241 0.152 0.291 0.434 0.845 0.743 0.253 0.662 0.234 0.627 0.812 0.992 0.525 0.244 0.498 0.464 0.98 0.196 0.25 0.369 0.581
Panther
Analysis Normal Normal Disease Normal Normal Normal Normal Disease Normal Normal Normal Normal Normal Disease Disease Normal Disease Normal Disease Disease Disease Disease Normal Normal Normal Disease Normal Normal Normal Disease

Table 1. (Continued) Mutants Serial number N40K R41K K42I S44L V45M V45A R47K L48F A49E A49V A49T A49P S50N Y51H R53G I54V T55S S56N S56R S57C C59G K61I K67R K67D K67T T68I I69V A71T A71V E73G

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