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Tumor Discovery Bioinformatics insights into CCL2 mutations

Specificity 0.92 0.77 0.91 0.91 0.98 0.63 0.76 0.78 1 0.95 0.91 0.68 0.94 0.56 0.7 0.35 0.69 0.85 0.48 0.66 0.52 0.6 0

Sensitivity 0.62 0.86 0.67 0.66 0.18 0.93 0.86 0.85 0 0.49 0.66 0.91 0.57 0.95 0.9 0.98 0.91 0.78 0.96 0.92 0.96 0.94 1

PolyPhen-2 Score 0.964 0.311 0.933 0.941 0.998 0.049 0.285 0.364 1 0.992 0.941 0.097 0.98 0.02 0.128 0.004 0.103 0.722 0.008 0.071 0.012 0.033 0

Possibly damaging Benign Possibly damaging Possibly damaging Possibly damaging Benign Benign Benign Possibly damaging Possibly damaging Possibly damaging Benign Possibly damaging Benign Benign Benign Benign Possibly damaging Benign Benign Benign Benign Benign
Analysis

Meta-SNP Score Analysis 0.772 Disease 0.325 Normal 0.691 Disease 0.728 Disease 0.732 Disease 0.245 Normal 0.162 Normal 0.342 Normal 0.75 Disease 0.62 Disease 0.63 Disease 0.309 Normal 0.519 Disease 0.1 Normal 0.372 Normal 0.063 Normal 0.112 Normal 0.343 Normal 0.066 Normal 0.084 Normal 0.055 Normal 0.05 Normal 0.081 Normal

Prediction of deleterious mutation SNAP Score Analysis 0.725 Disease 0.01 0.685 Disease 0.04 0.71 Disease 0.01 0.76 Disease 0.01 0.805 Disease 0 0.47 Normal 0.4 0.43 Normal 0.19 0.465 Normal 0.21 0.795 Disease 0 0.695 Disease 0.01 0.675 Disease 0.01 0.48 Normal 0.13 0.56 Disease 0.01 0.525 Disease 0.4 0.745 Disease 0.02 0.23 Normal 0.32 0.465 Normal 0.03 0.65 Disease 0.21 0.16 Normal 0

Analysis SIFT Score Disease Disease Disease Disease Disease Normal Normal Normal Disease Disease Disease Normal Disease Normal Disease Normal Disease Normal Normal Normal Normal Normal Normal

PhD-SNP Score 0.771 0.409 0.67 0.517 0.557 0.219 0.154 0.234 0.622 0.406 0.466 0.289 0.334 0.061 0.252 0.024 0.061 0.322 0.042 0.027 0.035 0.034 0.006

Analysis Disease Normal Disease Disease Disease Normal Normal Normal Disease Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal

Score 0.885 0.269 0.661 0.548 0.886 0.289 0.347 0.554 0.986 0.977 0.965 0.304 0.714 0.139 0.596 0.132 0.191 0.443 0.16 0.232 0.168 0.245 0.091
Panther
Analysis Disease Normal Disease Disease Disease Normal Normal Disease Disease Disease Disease Normal Disease Normal Disease Normal Normal Normal Normal Normal Normal Normal Normal

Table 1. (Continued) Mutants Serial number I74N D77E D77G P78S P78H K79E K79R K81N W82L V83A V83L Q84R D85Y M87V M87K D88N D88V H89P K92R T96A P97L P97T T99S

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Volume 3 Issue 4 (2024) 61 62 63 64 65 66 67 68 69 10 70 71 72 73 74 75 76 77 78 79 80 81 doi: 10.36922/td.3891