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Tumor Discovery CTC characterization for EGFR mutations

Table 5. Comparison of mutations detected in CTCs and tumor biopsies
Patient ID Exon EGFR EGFR mutation in CTCs Percentage of mutations Exon EGFR EGFR mutation Matched
CTC detected using NGS biopsy tumor biopsy (Yes or No)
1 WT WT Yes
3 WT WT Yes
8 WT WT Yes
9 21 L858R WT No
10 WT WT Yes
11 WT WT Yes
13 19 Deletion (E746_A750delELREA) WT No
14 WT WT Yes
15 19 Deletion (E746_A750delELREA) WT No
16 19 Deletion (E746_A750delELREA) WT No
17 19 Deletion (E746_A750delELREA) 20 Exon 20 No
insertion
21 L858R
19 19 Deletion (E746_A750delELREA) WT No
20 21 L858R WT No
21 WT WT Yes
22 WT WT Yes
24 19 Deletion (E746_A750delELREA), c. 2389T>A 2.01 WT No
20 1.3
25 20 c. 2375T>C 0.6 WT No
26 19 Deletion (E746_A750delELREA) 55.39 WT No
27 19 Deletion (E746_A750delELREA) 6.18 19 Exon 19 del Yes
28 19 Deletion (E746_A750delELREA) 3.4 WT No
19 P733L 1.74
29 21 c. 2573T>c 0.76 WT No
30 19 Deletion (E746_A750delELREA) 3.19 WT No
19 P733L 1.13
20 c2318A≥G 0.58
31 19 Deletion (E746_A750delELREA) 1.4 WT No
20 c. 2375T>c, c. 2327>G 0.55, 0.75
20 R766H 1.2
20 c2441T≥A 0.75
32 19 Deletion (E746_A750delELREA) 2.4 WT No
19 P735S 1.2
18 L703P 1.01
21 P848L 0.86
34 19 Deletion (E746_A750delELREA) 0.65 WT No
19 c. 2281G>A 0.58
21 c2573T≥c 0.55
36 19 Deletion (E746_A750delELREA) 2.65 WT No
19 c2281G≥A 1.17
37 19 Deletion (E746_A750delELREA) 2.65 WT No
18 c. 2123A>G 0.83
38 19 Deletion (E746_A750delELREA) 6.11 WT No
(cont'd...)
Volume 3 Issue 4 (2024) 11 doi: 10.36922/td.3987