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Tumor Discovery CTC characterization for EGFR mutations

Table 2. EGFR mutations detected in CTCs
Patient ID Exon Mutations Percentage of mutations No. of CTCs
detected using NGS counted
1 WT
3 WT
8 WT
9 21 L858R ND NR
10 WT
11 WT
13 19 Deletion (E746_A750delELREA) ND NR
14 WT
15 19 Deletion (E746_A750delELREA) ND NR
16 19 Deletion (E746_A750delELREA) ND NR
17 19 Deletion (E746_A750delELREA) ND NR
21 L858R ND NR
19 19 Deletion (E746_A750delELREA) ND NR
20 21 L858R ND NR
21 WT
22 WT
24 19 Deletion (E746_A750delELREA) C.2389T 2.01 7
20 > A 1.3
25 20 c. 2375T > C 0.6 4
26 19 Deletion (E746_A750delELREA) 55.39 402
27 19 Deletion (E746_A750delELREA) 6.18 59
28 19 Deletion (E746_A750delELREA) 3.4 3
19 P733L 1.74
29 21 c. 2573T > G 0.76 23
30 19 Deletion (E746_A750delELREA) 3.19 35
19 P733L 1.13
20 c. 2318A ≥ G 0.58
31 19 Deletion (E746_A750delELREA) 1.4 81
20 R766H 1.2
20 c. 2327G > A, c. 2375T > C 0.75, 0.55
32 19 Deletion (E746_A750delELREA) 2.4
19 P735S G696E 1.2
18 L703P 1.01
21 P848L 0.86
34 19 Deletion (E746_A750delELREA) 0.65
21,19 c. 2573T > c, c. 2281G > A 0.55, 1.21
36 19 Deletion (E746_A750delELREA) 2.65
19 c. 2281G ≥ A 1.17
37 19 Deletion (E746_A750delELREA) c. 2123A 2.65 90
18 > G 0.83
38 19 Deletion (E746_A750delELREA) 6.11 32
39 19 Deletion (E746_A750delELREA) 5.83 11
20 T790M 0.83
(cont'd...)

Volume 3 Issue 4 (2024) 8 doi: 10.36922/td.3987