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Advanced Neurology Futile recanalization of acute basilar artery occlusion

Figure 6. Association of ACGS-BAO and Ln(SIRI) with futile recanalization in subgroup analysis.
Abbreviations: ACGS-BAO: Angiographic Collateral Grading System for Basilar Artery Occlusion; CI: Confidence interval; ICA: Intracranial
atherosclerotic; NIHSS: National Institutes of Health Stroke Scale; OPT: Onset-to-groin puncture time; OR: Odds ratio; SIRI: Systemic inflammation
response index.

Table 3. ROC curve analysis of ACGS-BAO and Ln (SIRI)
Variables AUC Cutoff 95% CI Sensitivity Specificity P
ACGS-BAO 0.717 2.5 0.614 – 0.819 0.681 0.632 <0.001
Ln (SIRI) 0.692 0.730 0.589 – 0.795 0.653 0.711 0.001
Procedure time 0.696 67 0.592 – 0.801 0.859 0.474 0.001
ACGS-BAO and Ln (SIRI) combined 0.789 0.700 0.699 – 0.878 0.708 0.816 <0.001
Abbreviations: ACGS-BAO: Angiographic Collateral Grading System for Basilar Artery Occlusion; Ln (SIRI): Natural logarithm-transformed of
systemic inflammation response index; OR: Odds ratio; ROC: Receiver operating characteristic; SIRI: Systemic inflammation response index.

and the correlation between stroke and inflammation. 0.6216 vs. 0.5349, 0.6216 vs. 0.5628, 0.6216 vs. 0.5579, and
Consequently, SIRI has the potential to serve as a more 0.6216 vs. 0.5865, respectively) . Furthermore, higher
[41]
sensitive predictor of inflammation. SIRI had proven valuable in predicting poor clinical
The effectiveness of SIRI in reflecting the state of outcomes for patients with mild AIS following IVT
[42]
inflammation and immune balance has been validated (OR: 2.938, 95% CI: 1.805 – 4.782, P < 0.001) . Yi et al.
across various vascular diseases and cancers. Yun et al. demonstrated that a SIRI threshold <2.9 (OR: 2.27, 95%
conducted an analysis of 680 patients with aneurysmal CI: 1.29 – 5.17, P = 0.019) was an independent predictor
[43]
subarachnoid hemorrhage (aSAH) and demonstrated that of good prognosis in EVT for large artery occlusion .
a SIRI value ≥3.2 × 10 /L (OR: 1.82, 95% CI: 1.46 – 3.24; The pre-procedural application of SIRI as an auxiliary
9
P = 0.021) independently predicted poor prognosis after method for predicting prognosis has proven effective and
aSAH . In the cardiovascular domain, higher SIRI has holds promise for future clinical application.
[38]
proven effective in predicting major adverse cardiovascular This study is not without its limitations. First, it is
events in patients with acute coronary syndrome undergoing imperative to acknowledge that this study is a single-center
percutaneous coronary intervention . A retrospective retrospective study characterized by a small sample size
[39]
study identified SIRI as an independent predictor of (n = 110). This intrinsic limitation may introduce a degree
prognosis in gallbladder cancer . Zhang et al. reported that of selection bias. Second, a notable constraint lies in the
[40]
elevated SIRI was associated with a higher risk of mortality exclusive focus on SIRI without concurrent consideration
and sepsis, along with higher stroke severity. Notably, SIRI of pivotal inflammatory markers such as high-sensitivity
outperformed other inflammation biomarkers, including C-reactive protein, interleukin-1, interleukin-6, and tumor
NLR, platelet-to-lymphocyte ratio, LMR, and RDW (AUC: necrosis factors. The absence of these markers in the

Volume 2 Issue 4 (2023) 9 https://doi.org/10.36922/an.1641