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Advanced Neurology

ORIGINAL RESEARCH ARTICLE
Evoked potential response in patients with

idiopathic Parkinson’s disease and atypical
parkinsonian syndromes: A comparative study

Manoj Roy, Amar Kumar Misra, Joydeep Mukherjee*, Manamita Mandal,
Jasodhara Chaudhuri, Kartik Chandra Ghosh, and Bijendra Mohanty
Department of Neurology, Nil Ratan Sircar Medical College and Hospital, AJC Bose Road, Kolkata,
West Bengal, India

Abstract

Patients with idiopathic Parkinson’s disease (IPD) and atypical parkinsonian syndromes
(APSs) suffer from a range of disorders, especially in balance and locomotion, which
necessitate visual, auditory, and somatosensory inputs. In this study, IPD patients, APS
patients, and healthy controls (HCs) (n = 50 per group) underwent a series of assessments
for visual evoked potentials (VEP), brainstem auditory evoked response (BAER), and short-
latency somatosensory evoked potentials (SSEP). Results showed that VEP P100 latency was
prolonged in multiple system atrophy-cerebellar type (MSA-C), multiple system atrophy-
parkinsonian type (MSA-P), and corticobasal ganglionic degeneration (CBD) patients. The
latency of peaks III and V was prolonged in IPD, MSA-C, dementia with Lewy bodies (DLB),
and Parkinson’s disease dementia (PDD). BAER I-III and I-V interpeak latency were prolonged
in IPD, DLB, and PDD, whereas BAER I-III, III-V, and I-V interpeak latencies were increased
and the V/I amplitude ratio was decreased in MSA-C. The central sensory conduction time
*Corresponding author:
Joydeep Mukherjee (N20-N13) was increased in MSA-P and MSA-C in SSEP. IPD patients had prolonged VEP
(joydeepdoc@gmail.com) P100 latency (P < 0.001), lower VEP N75-P100 amplitude (P < 0.001), prolonged BAER I,
Citation: Roy M, Misra AK, II, II, IV, V peak latencies (P < 0.001), I-III, I-V interpeak latencies (P < 0.001), lower BAER V/I
Mukherjee J, et al., 2023, Evoked amplitude ratio (P < 0.001), and prolonged SSEP N13, N20, central sensory conduction
potential response in patients with time (N20-N13) (P < 0.001) than HCs. IPD patients also had prolonged BAER I, II, II, IV, V peak
idiopathic Parkinson’s disease and
atypical parkinsonian syndromes: latencies (P < 0.001), prolonged I-III, I-V interpeak latencies (P < 0.001), and shorter SSEP N13,
A comparative study. Adv Neuro, N20, central sensory conduction time (N20-N13) (P < 0.001) than APS patients. Moreover,
2(4): 1907. APS patients had prolonged VEP P100 and N145 latencies (P < 0.001) and decreased
https://doi.org/10.36922/an.1907
N75-N145 amplitude (P < 0.001) compared to HCs. APS patients also had prolonged BAER
Received: September 25, 2023 II, II, IV, V peak latencies (P < 0.001), prolonged I-III, III-V, I-V interpeak latencies (P < 0.001),
Accepted: November 28, 2023 decreased V/I amplitude ratio, and prolonged SSEP N13, N20, central sensory conduction
time (N20-N13) (P < 0.001) than HCs. Postural instability and gait disorder (PIGD) IPD had
Published Online: December 14,
2023 significantly prolonged BAER III, V peak latencies (P < 0.05), and prolonged III-V interpeak
latencies (P < 0.05) compared to tremor-dominant IPD. Overall, the IPD and APS patients
Copyright: © 2023 Author(s).
This is an Open-Access article had significant VEP, BAER, and SSEP abnormalities of demyelination and axonal variety in the
distributed under the terms of the visual, auditory, and somatosensory pathways. The changes were also correlated with the
Creative Commons Attribution disease duration and severity. Although the diseases are predominantly motor disorders
License, permitting distribution,
and reproduction in any medium, with significant non-motor components, these electrophysiological abnormalities
provided the original work is might open a new avenue to assess the non-motor symptoms.
properly cited.
Publisher’s Note: AccScience Keywords: Idiopathic Parkinson’s disease; Atypical parkinsonian syndromes; Visual evoked
Publishing remains neutral with potentials; P100; Brainstem auditory evoked response; Short-latency somatosensory
regard to jurisdictional claims in
published maps and institutional evoked potentials
affiliations.

Volume 2 Issue 4 (2023) 1 https://doi.org/10.36922/an.1907