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Advances in Radiotherapy
            & Nuclear Medicine                                                  Radiotherapy with neutron/gamma tubes



            ray  production before  being  employed for  therapeutic   3.   Martellini M, Sarotto M, Leung KN, Gherardi G. A compact
            uses. The mini neutron/gamma-ray tube system can      neutron generator for the Niort treatment of severe solid
            be conveniently located in a clinical facility or inside   cancers. Med Res Arch. 2023;11(3).
            the operational room of a hospital. If neutron/gamma      doi: 10.18103/mra.v11i3.3799
            radiotherapy is proven successful in removing all common   4.   Persuad A, Kwan JW, Leitner M,  et al. A  tandem-based
            types of tumors, it may become a standard therapeutic tool   compact dual-energy gamma generator.  Rev Sci Instrum.
            for cancer treatment.                                 2010;81:02B904.
            Acknowledgments                                       doi: 10.1063/1.3258028

            Fruitful discussions with Maurizio Martellini and members   5.   Leung KN. Production of H-  ions by thermal desorption
                                                                  process. AIP Adv. 2023;13:075123.
            of the Theranosti Centre (Milan, Italy) and the technical
            support by C&E Enterprises are deeply acknowledged.     doi: 10.1063/5.0162487
                                                               6.   Leung KN. New mini  neutron tubes with multiple
            Funding                                               applications. J Nucl Eng. 2024;5:197-208.

            This work is supported by Berkion Technology’s internal      doi: 10.3390/jne5030014
            funding. This work is supported by Berkion Technology’s   7.   Leung KN. New compact neutron generator system for
            internal funding. The authors are currently affiliated with   multiple applications. Nucl Technol. 2020;206:1607-1614.
            Berkion Technology, which was involved in designing and
            conducting the study.                              8.   National Research Council.  Radiation Source Use and
                                                                  Replacement: Abbreviated Version. Washington, DC: The
            Conflict of interest                                  National Academies Press; 2008.
                                                                  doi: 10.17226/11976
            The authors are currently affiliated with Berkion
            Technology. However, the authors declared that they   9.   Csikai J, editor. CRC Handbook of Fast Neutron Generator.
            have no known competing financial interests or personal   Vol. 1. Boca Raton, Florida: CRC Press Inc.; 1987.
            relationships that could have influenced the work reported   10.  Bin J, Obst-Huebl I, Mao JH, et al. A new platform for ultra-
            in this paper.                                        high dose rate radiobiological research using the BELLA PW
                                                                  laser proton beamline. Sci Rep Nat Portfolio. 2022;12:1484.
            Author contributions                                  doi: 10.1038/s41598-022-05181-3
            Conceptualization: All authors                     11.  Leung KN, Leung JK, Melville G. Feasibility study on medical
            Writing – original draft: Ka-Ngo Leung                isotope production using a compact neutron generator. Appl
            Writing – review & editing: James K. Leung            Radiat Isot. 2018;137C:23-27.

            Ethics approval and consent to participate            doi: 10.1016/j.apradiso.2018.02.026
                                                               12.  Lee CL, Zhou XL. Thick target yields for the 7Li(p,n)7Be
            Not applicable.                                       reaction near threshold. Nucl Instrum Methods Phys Res B.

            Consent for publication                               1999;152:1-11.
                                                               13.  Tanaka K, Kobayashi T, Sakurai Y, Nakagawa Y, Ishikawa M,
            Not applicable.                                       Hoshi M. Irradiation characteristics of BNCT using Near-
                                                                  Threshold  Li(p,n) Be direct neutrons: Application to intra-
                                                                                7
                                                                          7
            Availability of data                                  operative BNCT for malignant brain tumors. Phys Med Biol.
            Not applicable.                                       2002;47:3011-3032.
                                                                  doi: 10.1088/0031-9155/47/16/315
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            Volume 2 Issue 3 (2024)                         7                              doi: 10.36922/arnm.3920
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