Page 53 - GPD-2-3

Gene & Protein in Disease Effect of phytochemicals in diabetes

https://doi.org/10.2147/DMSO.S43731 AMPK activators in cardiovascular disease prevention.
Front Pharmacol, 12: 738420.
56. Jensen TE, Schjerling P, Viollet B, et al., 2008, AMPK α1
activation is required for stimulation of glucose uptake https://doi.org/10.3389/fphar.2021.738420
by twitch contraction, but not by H O , in mouse skeletal
2
2
muscle. PLoS One, 3(5): e2102. 62. Foretz M, Even PC, Viollet B, 2018, AMPK activation
reduces hepatic lipid content by increasing fat oxidation in
https://doi.org/10.1371/journal.pone.0002102 vivo. Int J Mol Sci, 19: 2826.
57. Sertel S, Fu Y, Zu Y, et al., 2011, Molecular docking and https://doi.org/10.3390/ijms19092826
pharmacogenomics of Vinca alkaloids and their monomeric
precursors, vindoline and catharanthine. Biochem 63. Zhou G, Myers R, Li Y, et al., 2001, Role of AMP-activated
Pharmacol, 81(6): 723–735. protein kinase in mechanism of metformin action. J Clin
Invest, 108: 1167–1174.
https://doi.org/10.1016/j.bcp.2010.12.026
https://doi.org/10.1172/JCI13505
58. Goboza M, Meyer M, Aboua YG, et al., 2020, In vitro
antidiabetic and antioxidant effects of different extracts 64. Habegger KM, Hoffman NJ, Ridenour CM, et al., 2012,
of Catharanthus roseus and its indole alkaloid, vindoline. AMPK enhances insulin-stimulated GLUT4 regulation via
Molecules, 25: 5546. lowering membrane cholesterol. Endocrinology, 153(5):
2130–2141.
https://doi.org/10.3390/molecules25235546
https://doi.org/10.1210/en.2011-2099
59. Goyal R, Kumar M, Mallick MA, 2023, Drug Innovation
Studies Targeting Diabetes: A Computational Docking 65. Oguntibeju OO, Aboua Y, Goboza M, 2019, Vindoline-a
Approach on Muti-drug Targets Including COVID natural product from Catharanthus roseus reduces
Inhibitors. North Carolina: Research Square. hyperlipidemia and renal pathophysiology in experimental
Type 2 diabetes. Biomedicines, 7: 59.
https://doi.org/10.21203/rs.3.rs-2457415/v1
https://doi.org/10.3390/biomedicines7030059
60. Goboza M, Aboua YG, Chegou N, et al., 2019, Vindoline
effectively ameliorated diabetes-induced hepatotoxicity 66. Mishra JN, Verma NK, 2017, A brief study on Catharanthus
by docking oxidative stress, inflammation and roseus: A review. Int J Res Pharm Pharm Sci, 2(2): 20–23.
hypertriglyceridemia in Type 2 diabetes-induced male 67. Sujatha S, Alhaji NM, 2022, Mechanism of action of
Wistar rats. Biomed Pharmacother, 112: 108638.
alkaloids in the management of diabetes mellitus. J Adv Sci
https://doi.org/10.1016/j.biopha.2019.108638 Res, 13(3): 4–7.
61. Heidary MR, Samimi Z, Asgary S, et al., 2022, Natural https://doi.org/10.55218/JASR.202213302

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