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Gene & Protein in Disease

ORIGINAL RESEARCH ARTICLE
Testosterone as a biomarker of colorectal cancer

in the South Indian population

4
5
2
Mohd Younis 1,2,3 *, Sevgi Gezici , Amrit Sudershan , Sanjeev Kumar Digra ,
7
Ashma Gupta , Arun Meyyazhagan , Parvinder Kumar *, and
6
2,3
1
Vijaya Anand *
1 Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil
Nadu, India
2 Institute of Human Genetics, University of Jammu, Jammu, Jammu and Kashmir, India
3 Department of Zoology, University of Jammu, Jammu, Jammu and Kashmir, India
4 Department of Medical Biology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
5 Department of Pediatrics, SMGS Hospital, Government Medical College, Jammu, Jammu and
Kashmir, India
6 Department of Zoology, Government College for Women, Gandhi Nagar, Jammu, Jammu and
Kashmir, India
7 Department of Translation Medicine and Surgery, University of Perugia, Perugia, Italy

Abstract

Colorectal cancer (CRC) is a highly life-threatening disease associated with
*Corresponding authors: a significant mortality rate. It has been proposed that testosterone levels
Mohd Younis may play a role in predisposing individuals to such devastating conditions.
(younisgenetic@gmail.com)
Parvinder Kumar Testosterone primarily governs the maturation of the male reproductive system
(parvinderkb2003@gmail.com) while also exerting physiological effects in both genders. In the present study,
Vijaya Anand
(avamiet@yahoo.com) we investigated testosterone levels in CRC patients among the South Indian
population. Blood samples were collected in the hospitals in Tamil Nadu, South
Citation: Younis M, Gezici S, India, and a cohort of healthy controls was selected for comparative analysis.
Sudershan A, et al., 2023,
Testosterone as a biomarker of A total of 130 subjects participated in the study, consisting of 65 CRC patients and
colorectal cancer in the South Indian an equal number of healthy controls. Approximately 7 mL of blood was collected
population. Gene Protein Dis, from each subject for radioimmunoassay. The results of radioimmunoassay on
2(3): 1082.
https://doi.org/10.36922/gpd.1082 the blood samples were analyzed using SPSS to assess differences between
discrete and continuous data variables. Chi-square and t-tests were conducted
Received: June 14, 2023
Accepted: September 19, 2023 for statistical evaluation. CRC patients exhibited significantly (P < 0.0001)
Published Online: September 29, reduced mean testosterone levels (06.68 ± 2.15 nmol/L) compared to controls
2023 (22.54 ± 8.85 nmol/L). Further stratification by smoking status revealed that
Copyright: © 2023 Author(s). non-smoker CRC patients had lower testosterone levels (06.81 ± 2.21 nmol/L)
This is an Open-Access article than non-smoking controls (10.15 ± 2.48 nmol/L), with a statistically significant
distributed under the terms of the
Creative Commons Attribution difference (P < 0.0001). Adjusting for alcohol consumption, CRC patients displayed
License, permitting distribution, decreased mean testosterone levels (06.31 ± 2.30 nmol/L) compared to controls
and reproduction in any medium, (07.96 ± 2.45 nmol/L), and this difference was found to be significant (P < 0.022).
provided the original work is
properly cited. These findings support the notion that reduced testosterone levels serve as a
critical risk biomarker in the pathogenesis of CRC.
Publisher’s Note: AccScience
Publishing remains neutral with
regard to jurisdictional claims in
published maps and institutional Keywords: Alcohol; Biomarker; Colorectal cancer; Screening; Smoking; Testosterone
affiliations.

Volume 2 Issue 3 (2023) 1 https://doi.org/10.36922/gpd.1082