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Global Translational Medicine                                           Deep learning by NMR-biochemical


































            Figure 4. An illustration of multiple-stage spectromics discovery, process, and translation for validation of quantitative imaging features based on the
            discovery of new relationships to other “omics” and translation into clinical predictive models as reference “virtual digital biopsies,” similar to actual
            biopsies to screen and assess therapeutic response. https://radiologykey.com/13-future-applications-radiomics-and-deep-learning-on-breast-mri/.


























            Figure 5. A scheme of computer-aided diagnosis (on the left) and deep learning (on the right) shows the approach of quantitative spectromics using
            segmentation features of dynamic contrast-enhanced magnetic resonance spectroscopy of tumors. https://radiologykey.com/13-future-applications-
            radiomics-and-deep-learning-on-breast-mri/.

            cancer tissue cross-checks with DCE-MRI image archive   extracted quantitative spectromic features or models,
            and  genomic  data  (Figure  10),  predicting  the  power  of   and  (iii)  computer-extracted  MRI  tumor  phenotype
            spectromic MRS features versus pathological stage and   for lymph node damage and pathological stage. Today,
            cancer subtypes.                                   the estimation of tumor size is the best predictor of the
                                                               pathologic stage. Moreover, the spectromic feature clearly
            3.1.3. A physician’s guide                         predicts the metabolic role in tumor stage I (benign) and II

            DL characterizes the breast tumors based on MRI radiomics   (premalignant) versus stage III (malignant). Breast tumor
            for (i) radiologist-measured tumor size, (ii) computer-  receptor status (human epidermal growth factor receptor 2


            Volume 2 Issue 3 (2023)                         8                         https://doi.org/10.36922/gtm.337
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