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Global Translational Medicine                                           Deep learning by NMR-biochemical






















































            Figure 3. An illustration of deep learning (DL). DL extracts digital features using artificial intelligence or computation algorithms to analyze the pathology
            in voxels on images to process the magnetic resonance spectroscopy data with demonstrated results in computer metabolomic datasets, medical images,
            natural language processing, and so forth (upper panels). Applications of deep learning in 2D nuclear magnetic resonance spectroscopy are shown as
            feature space of 27 metabolite-trained datasets derived from the total correlation spectroscopy spectrum of breast cancer tissue. The insets are the selected
            enlarged peaks overlapped in (F2, F1) dimensions (lower panel). https://radiologykey.com/13-future-applications-radiomics-and-deep-learning-on-
            breast-mri/.

            texture and metabolite density correlation. Dense breast   cancer, allowing for further discussion of the treatment
            tissues show higher citrate (Cit) and choline (Cho) peak   plan. Recently, the MRSI phenotyping resource the
            enhancement than fatty breast tissues.             cancer genome atlas/the cancer imaging archive
                                                               (TCGA/TCIA)  set  up  by  the  national  cancer  institute
            3.1.2. Breast tumor MRI phenotyping relative to    advocates spectromic biomarkers to predict the
            molecular subtyping for diagnosis and prognosis    pathological stage and allow quick patient management/
            The spectromics needs extensive data analysis to transform   treatment by neoadjuvant chemotherapy and/or radiation
                                                                               [18]
            the breast 4D DCE-MR images and molecular spectrum   therapy and surgery . The TCGA/TCIA cancer research
            features into phenotypic descriptors at the breast MRI   group established the relationships between computer-
            workstation.  One  spectromic  feature  represents  only   extracted quantitative MRSI spectromics with prognostic
            one clinical task. A  breast biopsy confirms the tumor’s   markers and clinical, molecular, and genomics gene
                                                                              [18]
            pathologic stage after  in vivo MRI imaging of breast   expression profiles . The biopsy-proven invasive breast


            Volume 2 Issue 3 (2023)                         7                         https://doi.org/10.36922/gtm.337
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